舌鳞状细胞癌 PF 诱导化疗与Ki-67及 EGFR 表达的关系研究
설린상세포암 PF 유도화료여Ki-67급 EGFR 표체적관계연구
Research of correlations between induction chemotherapy of PF regimen with expression of Ki-67 and EGFR in tongue squamous cell carcinoma
  • 万方数据
    浙江医学 절강의학
    ZHEJIANG MEDICAL JOURNAL
    2012年 23期 1886-1888 ,共3页

    徐金标%魏军水%孙鑫

    서금표%위군수%손흠



    Tongue squamous cel carcinoma%Induction chemotherapy%Ki-67%EGFR%Immunohistochemistry


    [ ] Objective To investigate the expressions of Ki-67 and EGFR in tongue squamous cel carcinoms treated by PF induction chemotherapy and their clinical significance. Methods Expressions of Ki-67 and EGFR were determined by im-munohistochemistry in 64 patients with tongue squamous cel carcinoma before and after PF induction chemotherapy. Results The overal response rate to induction chemotherapy was 81.2%. The response rate of patients with positive Ki-67 or EGFR ex-pression were higher than that with negative Ki-67 and Ki-67 expression before induction chemotherapy (P<0.05). The expres-sion of Ki-67 or EGFR were significantly reduced after induction chemotherapy (P<0.05). Conclusion The expression of Ki-67 and EGFR may be of predictive value for PF induction chemotherapy and inductive chemotherapy may affect Ki-67 and EGFR expression in patients with tongue squamous cel carcinoma.
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