CAJ | 학술논문

目的探讨 Pax2和 E-cadherin 在卵巢浆液性肿瘤中的表达及临床意义.方法采用免疫组织化学 EnVision 两步法检测10例正常卵巢组织、10例卵巢良性浆液性肿瘤、28例交界性浆液性肿瘤、72例浆液性腺癌中 Pax2和 E-cadherin 的表达情况,并分析其表达与浆液性腺癌的临床分期和组织学分级的关系.结果(1)Pax2和 E-cadherin 在正常卵巢组织、良性浆液性肿瘤、交界性浆液性肿瘤及浆液性腺癌中的阳性表达率分别为:0、40.0%、64.3%、77.8%和0、10.0%、71.4%、55.6%,Pax2和 E-cad-herin 的阳性率在4组间比较,差异均有统计学意义(均 P<0.05).(2)Pax2在浆液性腺癌中的表达率随临床分期、病理分级的升高而增加,差异有统计学意义(P<0.05);E-cadherin 在浆液性腺癌中的表达率随临床分期的升高而下降,差异有统计学意义(P<0.05),表达率随病理分级的升高有下降趋势,但差异无统计学意义(P >0.05).结论 Pax2和 E-cadherin 的表达可能从正常卵巢组织、良性浆液性肿瘤、交界性浆液性肿瘤到浆液性腺癌的发生及演变过程中起促进作用;在浆液性腺癌中,Pax2的高表达和 E-cadherin的低表达可能与浆液性腺癌的侵袭和转移有关,提示联合检测 Pax2和 E-cadherin 对判断浆液性腺癌的恶性程度和临床预后的评估有指导意义.
목적탐토 Pax2화 E-cadherin 재란소장액성종류중적표체급림상의의.방법채용면역조직화학 EnVision 량보법검측10례정상란소조직、10례란소량성장액성종류、28례교계성장액성종류、72례장액성선암중 Pax2화 E-cadherin 적표체정황,병분석기표체여장액성선암적림상분기화조직학분급적관계.결과(1)Pax2화 E-cadherin 재정상란소조직、량성장액성종류、교계성장액성종류급장액성선암중적양성표체솔분별위:0、40.0%、64.3%、77.8%화0、10.0%、71.4%、55.6%,Pax2화 E-cad-herin 적양성솔재4조간비교,차이균유통계학의의(균 P<0.05).(2)Pax2재장액성선암중적표체솔수림상분기、병리분급적승고이증가,차이유통계학의의(P<0.05);E-cadherin 재장액성선암중적표체솔수림상분기적승고이하강,차이유통계학의의(P<0.05),표체솔수병리분급적승고유하강추세,단차이무통계학의의(P >0.05).결론 Pax2화 E-cadherin 적표체가능종정상란소조직、량성장액성종류、교계성장액성종류도장액성선암적발생급연변과정중기촉진작용;재장액성선암중,Pax2적고표체화 E-cadherin적저표체가능여장액성선암적침습화전이유관,제시연합검측 Pax2화 E-cadherin 대판단장액성선암적악성정도화림상예후적평고유지도의의.
Objective To investigate the expression and clinical significance of Pax2 and E-cadherin in ovarian serous tumor. Methods Pax2 and E-cadherin were examined by immunohistochemistry (EnVision method) in 10 samples from normal ovarian tissue,10 from ovarian serous adenoma, 28 from ovarian serous borderline tumor and 72 from ovarian serous adenocarci-noma. The correlation of Pax2 and E-cadherin expression with clinical stage, pathological grade of serous adenocarcinoma were analyzed. Results The positive expression rates of Pax2 and E-cadherin in normal ovarian tissue, ovarian serous adenoma, o-varian serous borderline tumor and ovarian serous adenocarcinoma were 0, 40.0%, 64.3%, 77.8% and 0, 10.0%, 71.4%, 55.6%, respectively (P<0.05). The expression rate of Pax2 in serous adenocarcinoma was increased with the rising of clinical stage and pathological grade of the tumor (P<0.05); while the expression rate of E-cadherin in serous adenocarcinoma was decreased with the rising of clinical stage(P<0.05). Conclusion The expression of Pax2 and E-cadherin may be involved in evolution from nor-mal ovarian tissue, ovarian serous adenoma, ovarian serous borderline tumor to ovarian serous adenocarcinoma. In serous ade-nocarcinoma the high expression of Pax2 and low expression of E-cadherin may have correlation with the invasion and metasta-sis of serous adenocarcinoma,indicating that the combined detection of Pax2 and E-cadherin may of value in judgment the ma-lignancy and clinic prognosis of serous adenocarcinoma.