浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
1期
26-28
,共3页
硝酸甘油%血流动力学%偏头痛
硝痠甘油%血流動力學%偏頭痛
초산감유%혈류동역학%편두통
Glyceryl trinitrate%Hemodynamics%Migraine
目的观察硝酸甘油(GTN)偏头痛大鼠模型颈总动脉血流动力变化.方法采用皮下注射 GTN 法建立偏头痛大鼠模型,应用 CBI 脉冲多普勒血流计、BIOPAC 多导生理信号记录仪对空白组、生理盐水组、硝酸甘油组血压稳定10min 后连续6h 监测血流动力变化,运用 NOTOCORD-Hem 3.5系统提取1、2、3、4、5、6h 等时间点的血流速度、心率、收缩压、舒张压、平均动脉压.结果 GTN 皮下注射后1h 及2h 血流速度分别降低(-8.35±3.41)cm/s 和(-7.84±3.90)cm/s,而1、2、4h 硝酸甘油组血流速度变化率与生理盐水组和空白组相比均下降(P<0.05).GTN sc 后收缩压变化率、舒张压变化率、平均动脉压变化率在1、2、4h 三个时间点与生理盐水组和空白组相比均降低(均 P<0.05).结论 GTN 致偏头痛模型大鼠颈总动脉血流速度持续下降,为进一步研究该模型提供实验依据.
目的觀察硝痠甘油(GTN)偏頭痛大鼠模型頸總動脈血流動力變化.方法採用皮下註射 GTN 法建立偏頭痛大鼠模型,應用 CBI 脈遲多普勒血流計、BIOPAC 多導生理信號記錄儀對空白組、生理鹽水組、硝痠甘油組血壓穩定10min 後連續6h 鑑測血流動力變化,運用 NOTOCORD-Hem 3.5繫統提取1、2、3、4、5、6h 等時間點的血流速度、心率、收縮壓、舒張壓、平均動脈壓.結果 GTN 皮下註射後1h 及2h 血流速度分彆降低(-8.35±3.41)cm/s 和(-7.84±3.90)cm/s,而1、2、4h 硝痠甘油組血流速度變化率與生理鹽水組和空白組相比均下降(P<0.05).GTN sc 後收縮壓變化率、舒張壓變化率、平均動脈壓變化率在1、2、4h 三箇時間點與生理鹽水組和空白組相比均降低(均 P<0.05).結論 GTN 緻偏頭痛模型大鼠頸總動脈血流速度持續下降,為進一步研究該模型提供實驗依據.
목적관찰초산감유(GTN)편두통대서모형경총동맥혈류동력변화.방법채용피하주사 GTN 법건립편두통대서모형,응용 CBI 맥충다보륵혈류계、BIOPAC 다도생리신호기록의대공백조、생리염수조、초산감유조혈압은정10min 후련속6h 감측혈류동력변화,운용 NOTOCORD-Hem 3.5계통제취1、2、3、4、5、6h 등시간점적혈류속도、심솔、수축압、서장압、평균동맥압.결과 GTN 피하주사후1h 급2h 혈류속도분별강저(-8.35±3.41)cm/s 화(-7.84±3.90)cm/s,이1、2、4h 초산감유조혈류속도변화솔여생리염수조화공백조상비균하강(P<0.05).GTN sc 후수축압변화솔、서장압변화솔、평균동맥압변화솔재1、2、4h 삼개시간점여생리염수조화공백조상비균강저(균 P<0.05).결론 GTN 치편두통모형대서경총동맥혈류속도지속하강,위진일보연구해모형제공실험의거.
Objective To study hemodynamic changes of common carotid artery in migraine rat model induced by glyc-eryl trinitrate (GTN). Methods Migraine rat model was established with GTN (10mg/kg,sc). Hemodynamic changes of blank group,normal saline group and GTN group after stable blood pressure for 10 minutes were monitored continuously by CBI pulsed Doppler flowmeter and BIOPAC multiplying channel physiological signal recorder for 6 hours, blood flow velocity, heart rate, sys-tolic blood pressure, diastolic blood pressure and mean arterial pressure were extracted at 1,2,3,4,5,6 hours with NOTOCORD-Hem 3.5 soft system. Results Blood flow velocity descended (-8.35±3.41)cm/s and(-7.84±3.90)cm/s after 1h and 2h of GTN sc, At 1h, 2h, 4h blood flow velocity change rate had decreased compared with normal saline group and blank group (P<0.05). Systolic blood pressure change Rate, diastolic blood pressure change rate and mean arterial blood pressure change rate in GTN group were lower more than normal saline group and blank group in the three time points of 1h, 2h, 4h (P<0.05). Conclusion Blood flow velocity of common carotid artery has continued to decline induced by GTN for the further study of migraine rat model provides experimental evidence.
