CAJ | 학술논문

目的观察间断使用1%阿托品眼用凝胶联合灰变渐进片治疗青少年低、中度近视的临床疗效.方法选择青少年低、中度近视患者134例(268只眼),按就诊先后分为 A、B 两组各67例(134只眼),A 组予以间断使用1%阿托品眼用凝胶联合灰变渐进片治疗,停用阿托品期间予以晶体操训练,B 组予以单光近视眼镜治疗.随访1年,每3个月复查视力、裂隙灯检查晶体、视网膜、黄斑等情况,测量眼压、屈光度、角膜曲率和眼轴长度.结果1年后,A 组的近视增长度数和眼轴增长分别为(0.38±0.15)D 和(0.13±0.09)mm ;B 组的近视增长度数和眼轴增长分别为(1.08±0.35)D 和(0.39±0.28)mm,两组间差异均有统计学意义(均 P<0.01).平均角膜曲率变化 A、B 组分别为(0.05±0.06)D、(0.06±0.07)D,两组间差异无统计学意义(P >0.05).1年内 A、B 组均未发现明显眼部并发症.结论间断使用1%阿托品眼用凝胶联合灰变渐进片能有效减缓青少年近视度数加深,减慢眼轴增长.
목적관찰간단사용1%아탁품안용응효연합회변점진편치료청소년저、중도근시적림상료효.방법선택청소년저、중도근시환자134례(268지안),안취진선후분위 A、B 량조각67례(134지안),A 조여이간단사용1%아탁품안용응효연합회변점진편치료,정용아탁품기간여이정체조훈련,B 조여이단광근시안경치료.수방1년,매3개월복사시력、렬극등검사정체、시망막、황반등정황,측량안압、굴광도、각막곡솔화안축장도.결과1년후,A 조적근시증장도수화안축증장분별위(0.38±0.15)D 화(0.13±0.09)mm ;B 조적근시증장도수화안축증장분별위(1.08±0.35)D 화(0.39±0.28)mm,량조간차이균유통계학의의(균 P<0.01).평균각막곡솔변화 A、B 조분별위(0.05±0.06)D、(0.06±0.07)D,량조간차이무통계학의의(P >0.05).1년내 A、B 조균미발현명현안부병발증.결론간단사용1%아탁품안용응효연합회변점진편능유효감완청소년근시도수가심,감만안축증장.
Objective To assess the efficacy of intermittent administration of 1% atropine combined with grey pho-tochromic and progressive multifocal lenses for juvenile myopia. Methods A total of 134 children and adolescents with slight to moderate myopia were randomly divided into 2 groups: group A (67 cases, 134 eyes) was treated by 1% atropine discontinuously combined with grey photochromic and progressive multifocal lenses and accommodation training during atropine discontinuance;group B (67cases,134 eyes) was treated by single focal lenses. The visual acuity, lens, retina, macular lutea, intraocular pressure, myopic diopters, corneal curvature and the axial length were examined every 3 month and the fol ow-up time was 1 year. Results After 1 year, the progression of myopia in group A and group B was (0.38±0.15)D and (1.08±0.35)D respectively; the extension of the axial length in group A and group B was(0.13±0.09)mm and(0.39±0.28)mm, respectively(both P<0.01). The changes of average corneal curvature in group A and group B were(0.05±0.06)D and(0.06±0.07)D, respectively(P >0.05). There were no other complications, except two patients had photophobia in group A. Conclusion The progression of myopia and the exten-sion of the axial length can be control ed effectively with intermittent administration of 1% atropine combined with grey pho-tochromic and progressive multifocal lenses for juvenile myopia.