CAJ | 학술논문

目的探讨意外胆囊癌组织层粘连蛋白受体(LN-R)表达与肿瘤组织学类型、分化程度、临床分期及转移的关系.方法对49例意外胆囊癌患者的临床资料进行回顾性分析,采用免疫组织化学法(EnVision 二步法)对胆囊癌组织进行LN-R 的检测.结果 LN-R 的阳性表达率为71.4%(35/49),LN-R 的阳性表达与肿瘤临床分期密切相关;59.2%(29/49)的患者术后发现肿瘤转移;LN-R 阳性组及 LN-R 阴性组肿瘤转移率分别为68.6%(24/35)及35.7%(5/14),两组比较差异有统计学意义(P<0.05).结论意外胆囊癌组织 LN-R 的表达与否与肿瘤临床分期及转移率有关,LN-R 的阳性表达提示转移可能性大,需严格把握再次根治手术指征.
목적탐토의외담낭암조직층점련단백수체(LN-R)표체여종류조직학류형、분화정도、림상분기급전이적관계.방법대49례의외담낭암환자적림상자료진행회고성분석,채용면역조직화학법(EnVision 이보법)대담낭암조직진행LN-R 적검측.결과 LN-R 적양성표체솔위71.4%(35/49),LN-R 적양성표체여종류림상분기밀절상관;59.2%(29/49)적환자술후발현종류전이;LN-R 양성조급 LN-R 음성조종류전이솔분별위68.6%(24/35)급35.7%(5/14),량조비교차이유통계학의의(P<0.05).결론의외담낭암조직 LN-R 적표체여부여종류림상분기급전이솔유관,LN-R 적양성표체제시전이가능성대,수엄격파악재차근치수술지정.
Objective To investigate the expression of laminin receptor (LN-R) and its relation to clinicopathological fea-tures of unexpected gal bladder carcinoma (UCG). Methods The expression of LN-R was detected by immunohistochemical assay in 49 patients with UCG; its relation to clinicopathological features of UCG patients was analyzed. Results The positive rate of LN-R expression was 71.4% in 49 cases. The expression of LN-R was correlated with the clinical stage of carcinoma. The metastasis rate of UGC accounted for 59.2% (29/49) after surgery; 68.6% (24/35) patients with LN-R expression had metas-tasis compared to 35.7% (5/14) in those without LN-R expression (P<0.05). Conclusion The expression of LN-R may predict postoperative metastasis in patients with UCG and suggests the necessity of secondary radical resection.