浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
2期
111-113
,共3页
大肠肿瘤%肿瘤抑制基因%Ezrin蛋白%免疫组织化学
大腸腫瘤%腫瘤抑製基因%Ezrin蛋白%免疫組織化學
대장종류%종류억제기인%Ezrin단백%면역조직화학
Colorectal neoplasms%Tumor suppressor gene%Ezrin%Immunohistochemistry
目的探讨大肠癌组织中 Ezrin 和 PTEN 蛋白表达的意义.方法采用免疫组化 SP 法检测80例大肠癌组织中Ezrin 和 PTEN 蛋白的表达,并分析其与临床和病理特点的关系.结果大肠癌组织中 Ezrin 蛋白表达阳性率为77.5%(62/80),显著高于正常大肠黏膜组织(P<0.01);PTEN 蛋白表达的阳性率为46.3%(37/80),显著低于正常大肠黏膜组织(P<0.01);Ezrin 蛋白高表达 PTEN 蛋白低表达与大肠癌 Dukes 分期、浆膜浸润、淋巴结转移有关(均 P<0.01),而与年龄和组织学类型无关(均 P >0.05);Ezrin和 PTEN 蛋白表达呈负相关(P<0.01).结论 Ezrin 和 PTEN 蛋白表达与大肠癌临床病理特征和生物学行为有密切关系,联合检测 Ezrin 和 PTEN 蛋白的表达,可用于评估大肠癌侵袭转移能力,对大肠癌的预后判断具有一定意义.
目的探討大腸癌組織中 Ezrin 和 PTEN 蛋白錶達的意義.方法採用免疫組化 SP 法檢測80例大腸癌組織中Ezrin 和 PTEN 蛋白的錶達,併分析其與臨床和病理特點的關繫.結果大腸癌組織中 Ezrin 蛋白錶達暘性率為77.5%(62/80),顯著高于正常大腸黏膜組織(P<0.01);PTEN 蛋白錶達的暘性率為46.3%(37/80),顯著低于正常大腸黏膜組織(P<0.01);Ezrin 蛋白高錶達 PTEN 蛋白低錶達與大腸癌 Dukes 分期、漿膜浸潤、淋巴結轉移有關(均 P<0.01),而與年齡和組織學類型無關(均 P >0.05);Ezrin和 PTEN 蛋白錶達呈負相關(P<0.01).結論 Ezrin 和 PTEN 蛋白錶達與大腸癌臨床病理特徵和生物學行為有密切關繫,聯閤檢測 Ezrin 和 PTEN 蛋白的錶達,可用于評估大腸癌侵襲轉移能力,對大腸癌的預後判斷具有一定意義.
목적탐토대장암조직중 Ezrin 화 PTEN 단백표체적의의.방법채용면역조화 SP 법검측80례대장암조직중Ezrin 화 PTEN 단백적표체,병분석기여림상화병리특점적관계.결과대장암조직중 Ezrin 단백표체양성솔위77.5%(62/80),현저고우정상대장점막조직(P<0.01);PTEN 단백표체적양성솔위46.3%(37/80),현저저우정상대장점막조직(P<0.01);Ezrin 단백고표체 PTEN 단백저표체여대장암 Dukes 분기、장막침윤、림파결전이유관(균 P<0.01),이여년령화조직학류형무관(균 P >0.05);Ezrin화 PTEN 단백표체정부상관(P<0.01).결론 Ezrin 화 PTEN 단백표체여대장암림상병리특정화생물학행위유밀절관계,연합검측 Ezrin 화 PTEN 단백적표체,가용우평고대장암침습전이능력,대대장암적예후판단구유일정의의.
Objective To investigate the expression of Ezrin and PTEN proteins in colorectal adenocarcinoma and its sig-nificance. Methods The expression of Ezrin and PTEN proteins was examined immunohistochemical y with SP method in 80 cas-es of colorectal adenocarcinoma, and the relationships of the expression with clinicopathological characteristics of tumor was an-alyzed. Results The positive rates of Ezrin and PTEN protein expression in 80 cases of colorectal adenocarcinoma were 77.5%(62/80) and 46.3%(37/80) respectively. They were not correlated with age or histological type(P>0.05). The high level of Ezrin pro-tein expression and the low level of PTEN protein expression were correlated significantly with the Dukes' stage, serosa infiltration, lymph node metastasis of colorectal adenocarcinoma (P<0.01). The expressions of Ezrin protein was negatively correlated with that of PTEN protein(P<0.01). Conclusion The expressions of Ezrin and PTEN are correlated with the clinicopathological charac-teristics and biologic behaviors of colorectal adenocarcinoma. The combined detection of Ezrin and PTEN proteins may be helpful in evaluation of prognosis and aggressive potential of colorectal adenocarcinoma.
