CAJ | 학술논문

目的探讨肿瘤转移消失(MIM)蛋白在直肠癌组织中的表达及其结合临床分期对直肠癌预后的指导意义.方法采用免疫组织化学方法检测MIM蛋白在直肠癌组织,直肠腺瘤组织,直肠正常组织中的表达,并用单因素分析其与临床病理参数的关系.用Spearman等级相关分析MIM蛋白表达水平与直肠癌患者TNM分期的关系.Kaplan-Meier生存曲线分析直肠癌患者5年生存率情况.结果直肠癌组织MIM蛋白表达阳性率(83.2%)较直肠正常组织的21.6%和直肠腺瘤组织的28.8%均明显增高(均P<0.05);MIM蛋白表达水平与直肠癌患者是否处于肿瘤早期、是否有3枚以上淋巴转移和肿瘤分化程度有关(均P<0.05),与直肠癌患者的性别、年龄、肿瘤直径、CEA水平、肿瘤位置高低均无关(均P>0.05).MIM蛋白表达水平与临床TNM分期呈正相关,即临床TNM越晚期MIM蛋白表达水平越高(P<0.05).MIM蛋白阳性患者5年生存率明显低于阴性及弱阳性患者(P<0.05).结论 MIM蛋白高表达可能与直肠癌的发生及生物学行为有关,并提示预后不良.
목적탐토종류전이소실(MIM)단백재직장암조직중적표체급기결합림상분기대직장암예후적지도의의.방법채용면역조직화학방법검측MIM단백재직장암조직,직장선류조직,직장정상조직중적표체,병용단인소분석기여림상병리삼수적관계.용Spearman등급상관분석MIM단백표체수평여직장암환자TNM분기적관계.Kaplan-Meier생존곡선분석직장암환자5년생존솔정황.결과직장암조직MIM단백표체양성솔(83.2%)교직장정상조직적21.6%화직장선류조직적28.8%균명현증고(균P<0.05);MIM단백표체수평여직장암환자시부처우종류조기、시부유3매이상림파전이화종류분화정도유관(균P<0.05),여직장암환자적성별、년령、종류직경、CEA수평、종류위치고저균무관(균P>0.05).MIM단백표체수평여림상TNM분기정정상관,즉림상TNM월만기MIM단백표체수평월고(P<0.05).MIM단백양성환자5년생존솔명현저우음성급약양성환자(P<0.05).결론 MIM단백고표체가능여직장암적발생급생물학행위유관,병제시예후불량.
Objective To investigate the expression of MIM (missing in metastasis) protein in rectal carcinoma and its clinicopathological significance. Methods The expression of MIM protein was detected by immunohistochemistry in tissue sam-ples of rectal carcinoma (n=143 ), rectal adenoma (n=14 ) and normal rectal mucosa (n=37). Correlation between MIM expres-sion and clinicopathological parameters was analyzed with Spearman rank regression. Postoperative 5-year survival was evalu-ated using Kaplan-Meier survival curve. Results The expression of MIM in rectal carcinoma was higher than those in normal rectal tissue (U=179.000, P<0.05) and rectal adenoma (U=112.500, P<0.05). The expression of MIM protein was correlated with clinical stage, lymphatic metastasis and tumor differentiation (separately U=256.000, 227.000, 236.500, al P<0.05), but not cor-related with gender,age,tumor diameter, CEA level and tumor location(P>0.05).MIM expression was also correlated with TNM stage of rectal cancer (r=0.369, P<0.05).The 5-year survival in patients with positive MIM expression was significantly poorer than those with negative or weakly positive expression (32.6% vs 67.8%,χ2=6.712, P<0.05). Conclusion High expression of MIM protein may be associated in progression of rectal carcinoma and poor prognosis.