浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
3期
171-174
,共4页
胃癌%Oct4%进展%预后
胃癌%Oct4%進展%預後
위암%Oct4%진전%예후
Gastric carcinoma%Oct4%Progression%Prognosis
目的探讨干细胞标记物Oct4在胃癌组织中的表达及其与胃癌浸润、转移及预后的关系.方法应用免疫组织化学SP法检测206例胃癌组织和其中40例癌旁非肿瘤胃黏膜Oct4的表达,并对Oct4表达水平与胃癌临床病理参数及患者生存率的关系作统计分析.结果在40例非肿瘤胃黏膜组织中,13例(32.5%)Oct4表达阳性,均为低表达.在206例胃癌组织中,155例(75.2%)存在Oct4表达,其中高表达126例(61.17%),Oct4在胃癌组织中的表达水平明显高于癌旁非肿瘤胃黏膜组织(P<0.05).Oct4蛋白的表达与胃癌的分化程度、浸润深度、淋巴结转移、远处转移及TNM分期有关(均P<0.05),而与患者年龄、性别、肿瘤部位、肿瘤大小和组织学类型无关(均P>0.05).I、Ⅱ和Ⅲ期Oct4高表达胃癌患者5年生存率显著低于Oct4低表达者(均P<0.05),Ⅳ期胃癌患者的5年生存率与Oct4表达水平无关(均P>0.05),多变量分析表明Oct4表达、淋巴结转移、远处转移和TNM分期是胃癌患者独立的预后因素.结论 Oct4的表达与胃癌淋巴结和远处转移及预后相关,Oct4可以作为胃癌预后判断有价值的分子标记物.
目的探討榦細胞標記物Oct4在胃癌組織中的錶達及其與胃癌浸潤、轉移及預後的關繫.方法應用免疫組織化學SP法檢測206例胃癌組織和其中40例癌徬非腫瘤胃黏膜Oct4的錶達,併對Oct4錶達水平與胃癌臨床病理參數及患者生存率的關繫作統計分析.結果在40例非腫瘤胃黏膜組織中,13例(32.5%)Oct4錶達暘性,均為低錶達.在206例胃癌組織中,155例(75.2%)存在Oct4錶達,其中高錶達126例(61.17%),Oct4在胃癌組織中的錶達水平明顯高于癌徬非腫瘤胃黏膜組織(P<0.05).Oct4蛋白的錶達與胃癌的分化程度、浸潤深度、淋巴結轉移、遠處轉移及TNM分期有關(均P<0.05),而與患者年齡、性彆、腫瘤部位、腫瘤大小和組織學類型無關(均P>0.05).I、Ⅱ和Ⅲ期Oct4高錶達胃癌患者5年生存率顯著低于Oct4低錶達者(均P<0.05),Ⅳ期胃癌患者的5年生存率與Oct4錶達水平無關(均P>0.05),多變量分析錶明Oct4錶達、淋巴結轉移、遠處轉移和TNM分期是胃癌患者獨立的預後因素.結論 Oct4的錶達與胃癌淋巴結和遠處轉移及預後相關,Oct4可以作為胃癌預後判斷有價值的分子標記物.
목적탐토간세포표기물Oct4재위암조직중적표체급기여위암침윤、전이급예후적관계.방법응용면역조직화학SP법검측206례위암조직화기중40례암방비종류위점막Oct4적표체,병대Oct4표체수평여위암림상병리삼수급환자생존솔적관계작통계분석.결과재40례비종류위점막조직중,13례(32.5%)Oct4표체양성,균위저표체.재206례위암조직중,155례(75.2%)존재Oct4표체,기중고표체126례(61.17%),Oct4재위암조직중적표체수평명현고우암방비종류위점막조직(P<0.05).Oct4단백적표체여위암적분화정도、침윤심도、림파결전이、원처전이급TNM분기유관(균P<0.05),이여환자년령、성별、종류부위、종류대소화조직학류형무관(균P>0.05).I、Ⅱ화Ⅲ기Oct4고표체위암환자5년생존솔현저저우Oct4저표체자(균P<0.05),Ⅳ기위암환자적5년생존솔여Oct4표체수평무관(균P>0.05),다변량분석표명Oct4표체、림파결전이、원처전이화TNM분기시위암환자독립적예후인소.결론 Oct4적표체여위암림파결화원처전이급예후상관,Oct4가이작위위암예후판단유개치적분자표기물.
Objective To investigate the expression of Octamer-4 (Oct4) in gastric cancer and its relationship with tumor invasion, metastasis and prognosis. Methods Immunohistochemistry was used to analyze the expression of Oct4 in 206 cases of gastric cancer. Results Oct4 protein was detected in 75.2% (155/206) of gastric cancer cases, including 61.17%(126/206) with high expression;while Oct4 was detected in 32.5%(13/40) non-cancerous mucosa, and was expressed in low levels. Com-pared to non-cancerous tissue the Oct4 expression was higher in gastric cancer tissue (P<0.05). The expression of Oct4 was correlated with histological differentiation, depth of invasion, lymph node metastasis, distant metastasis and TNM stage of gastric cancer. In stages I,II and III cancer, the 5-year survival rate of patients with a high expression of Oct4 was significantly lower than those with low expression. In stage IV, Oct4 expression was not correlate with the 5 year survival rate of patients. Multivariate analysis suggested that lymph node metastasis, distant metastasis, TNM stage, and up-regulation of Oct4 expression were in-dependent prognostic indicators for the disease. Conclusion Expression of Oct4 in gastric cancer is significantly associated with lymph node metastasis, distant metastasis and poor prognosis. Oct4 may be an useful markers for progression and progno-sis of the cancer.
