CAJ | 학술논문

目的探讨血液灌流(HP)对维持性血液透析(MHD)患者微炎症与贫血的影响.方法选取血液净化中心MHD患者40例.根据C反应蛋白(CRP)水平分为两组,CRP正常组(CRP<5mg/L)16例和CRP增高组(CRP≥5mg/L)24例.CRP增高组患者在治疗前后采集血清,并进行HP联合血液透析治疗;CRP正常组患者行MHD治疗.两组患者均测定超敏C反应蛋白(hs-CRP)、血红蛋白(Hb)、血清肌酐(Scr)、血清白蛋白(ALB).结果 CRP正常组Hb、ALB较CRP增高组高,而Scr则较低,差异均有统计学意义(均P<0.05).CRP增高组HP治疗前的hs-CRP、Hb、ALB与治疗后相比,差异有统计学意义(P<0.05).结论 HP联合血液透析治疗有助于改善MHD患者的微炎症及贫血状态.
목적탐토혈액관류(HP)대유지성혈액투석(MHD)환자미염증여빈혈적영향.방법선취혈액정화중심MHD환자40례.근거C반응단백(CRP)수평분위량조,CRP정상조(CRP<5mg/L)16례화CRP증고조(CRP≥5mg/L)24례.CRP증고조환자재치료전후채집혈청,병진행HP연합혈액투석치료;CRP정상조환자행MHD치료.량조환자균측정초민C반응단백(hs-CRP)、혈홍단백(Hb)、혈청기항(Scr)、혈청백단백(ALB).결과 CRP정상조Hb、ALB교CRP증고조고,이Scr칙교저,차이균유통계학의의(균P<0.05).CRP증고조HP치료전적hs-CRP、Hb、ALB여치료후상비,차이유통계학의의(P<0.05).결론 HP연합혈액투석치료유조우개선MHD환자적미염증급빈혈상태.
Objective To investigate the effects of hemoperfusion (HP) on micro-infalmmation and anemia in maintenance hemodialysis (MHD) patients. Methods Forty MHD patients, including 16 cases with normal C-reactive protein (CRP) levels (CRP<5mg/L)and 24 cases with high CRP levels (CRP≥5mg/L)were enrol ed in the study. Patients with high CRP underwent HP combined MHD and those with normal CRP received MHD only. Serum ultra-sensitivity C-reactive protein (hs-CRP), hemoglobin (Hb), creatinine (Scr), albumin (ALB) were determined before and after treatment. Results The Hb, ALB levels were higher and Scr was lower in MHD patients with normal CRP than those with higher CRP (al P<0.05). There were significant differences in CRP, Hb and ALB levels of high CRP group before and after treatment (al P<0.05). Conclusion Hemoperfusion combined with hemodialysis can reduce serum hs-CRP levels and improve the degree of anemia in MHD patients with micro-infalmmatory state.