CAJ | 학술논문

目的探讨新生儿败血症的病原菌分布及其耐药性,为临床经验性诊治提供科学依据.方法选取疑诊为新生儿败血症的住院患儿常规进行血培养.将系统提示阳性的血培养瓶及时取出,划种于固体培养基上,经细菌自动鉴定系统(Vitek 2-com-pact)进行菌种鉴定和药敏试验.结果确诊为新生儿败血症113例,共培养出细菌117株,血培养阳性率10.2%,革兰阳性菌92.3%,革兰阴性菌仅占7.7%.凝固酶阴性葡萄球菌93株,占79.5%,其中表皮葡萄球菌和溶血葡萄球菌最多见,分别为49.6%和12.4%.葡萄球菌对苯唑西林的耐药率高达81%,所有阳性球菌均对万古霉素敏感,亚胺培南对革兰阴性杆菌保持较强抗菌活性.结论葡萄球菌是新生儿败血症的主要致病菌,且该菌对苯唑西林耐药率高,临床医师应根据药敏试验结果选择抗生素.
목적탐토신생인패혈증적병원균분포급기내약성,위림상경험성진치제공과학의거.방법선취의진위신생인패혈증적주원환인상규진행혈배양.장계통제시양성적혈배양병급시취출,화충우고체배양기상,경세균자동감정계통(Vitek 2-com-pact)진행균충감정화약민시험.결과학진위신생인패혈증113례,공배양출세균117주,혈배양양성솔10.2%,혁란양성균92.3%,혁란음성균부점7.7%.응고매음성포도구균93주,점79.5%,기중표피포도구균화용혈포도구균최다견,분별위49.6%화12.4%.포도구균대분서서림적내약솔고체81%,소유양성구균균대만고매소민감,아알배남대혁란음성간균보지교강항균활성.결론포도구균시신생인패혈증적주요치병균,차해균대분서서림내약솔고,림상의사응근거약민시험결과선택항생소.
Objective To investigate the distribution and antibiotics resistance of bacteria isolated from neonates with septicemia. Methods Blood samples from neonates suspected septicemia admitted from January 2010 to July 2011were col-lected and cultured. The blood samples with positive alarms in the Vitek system were inoculated on solid medium. Bacterial strains were identified and antibiotics susceptibility was tested with Vitek system. Results A total of 117 strains were isolated from 113 neonates with septicemia with a positive blood culture rate of 10.2%. The predominant strains (92.3%) were gram-posi-tive, while the gram-negative strains accounted for only 7.7%. Ninety-three isolates were coagulase-negative staphylococci and most of them were staphylococcus epidermidis (49.6%) fol owed by staphylococcus hemolyticus (12.4%) and 81%of the staphy-lococcus strains were resistant to oxacilin. Al gram-positive strains were susceptible to vancomycin and most of the gram-neg-ative bacteria were susceptible to imipenem. Conclusion Staphylococcus is the most common pathogen causing neonatal sep-ticemia, with a high rate of resistance to oxacil n.