CAJ | 학술논문

目的分析静息血压控制正常的运动高血压患者临床特征及动脉弹性.方法原发性高血压患者101例,根据运动血压结果分为运动高血压组(运动收缩压峰值≥200mmHg,48例)和运动血压正常组(运动收缩压峰值<200 mmHg,53例),用心-踝血管指数(CAVI)作为反映大动脉硬度的指标.结果与运动中血压反应正常组相比,出现运动高血压患者中,老年人、吸烟、肥胖、高HbA1C、高LDL-C、合并脑卒中的比例显著增多,服用他汀类药物比例减少(P<0.05).运动高血压组亚极量运动收缩压、收缩压增量、血压升高速率较运动血压正常组明显偏高,分别为(213.73±5.8)、(177.9±8.4)mmHg,(71.5±6.6)、(44.7±7.6)mmHg,(8.6±1.9)、(4.9±1.0)mmHg/min(均P<0.05);运动高血压组患者CAVI显著大于运动血压正常组,分别为(10.61±0.78)、(9.03±0.91)m/s (P<0.05).亚极量运动收缩压与CAVI、BMI、HbA1c、是否服用他汀类药物相关(P<0.05或0.01).结论即使静息血压控制正常,出现运动高血压的患者中,心血管危险因素比例显著增多,动脉僵硬度增高.运动血压与动脉弹性、BMI、是否服用他汀类药物、HbA1C密切相关.
목적분석정식혈압공제정상적운동고혈압환자림상특정급동맥탄성.방법원발성고혈압환자101례,근거운동혈압결과분위운동고혈압조(운동수축압봉치≥200mmHg,48례)화운동혈압정상조(운동수축압봉치<200 mmHg,53례),용심-과혈관지수(CAVI)작위반영대동맥경도적지표.결과여운동중혈압반응정상조상비,출현운동고혈압환자중,노년인、흡연、비반、고HbA1C、고LDL-C、합병뇌졸중적비례현저증다,복용타정류약물비례감소(P<0.05).운동고혈압조아겁량운동수축압、수축압증량、혈압승고속솔교운동혈압정상조명현편고,분별위(213.73±5.8)、(177.9±8.4)mmHg,(71.5±6.6)、(44.7±7.6)mmHg,(8.6±1.9)、(4.9±1.0)mmHg/min(균P<0.05);운동고혈압조환자CAVI현저대우운동혈압정상조,분별위(10.61±0.78)、(9.03±0.91)m/s (P<0.05).아겁량운동수축압여CAVI、BMI、HbA1c、시부복용타정류약물상관(P<0.05혹0.01).결론즉사정식혈압공제정상,출현운동고혈압적환자중,심혈관위험인소비례현저증다,동맥강경도증고.운동혈압여동맥탄성、BMI、시부복용타정류약물、HbA1C밀절상관.
Objective To investigate the clinical characteristics and arterial elasticity in hypertensive patients with wel-control ed blood pressure at rest and their response to exercise. Methods Hypertensive patients with wel-control ed blood pressure at rest were divided into two groups according to peak systolic blood pressure(SBP) after sub-maximal treadmil exercise test:hypertensive response group (peak exercise SBP≥200mmHg, n=48) and normal response group (peak exercise SBP<200mmHg, n=53). Cardio-ankle vascular index(CAVI) and blood chemistry were measured in al patients. Results There was significant differences in age, BMI, LDL-C, smoking, stroke, taking statins between two groups (P<0.05). Hypertensive re-sponse group showed higher peak SBP after sub-maximal treadmil exercise test, faster increase of blood pressure than normal response group[(213.73±5.8) vs (177.9±8.4) mmHg and (8.6±1.9) vs (4.9±1.0) mmHg/min, P<0.05]. Patients with hyperten-sive response showed higher CAVI [(10.61±0.78)m/s vs (9.03±0.91)m/s, P<0.05] compared to those with normal response. Sub-maximal exercise systolic blood pressure was correlated with CAVI and taking statins closely (r=0.695 and 0.248,respec-tively, P<0.05). Conclusion Patients with hypertensive response showed higher proportion in CV risk factors and worse arterial elasticity even if their resting blood pressure was control ed wel . Hypertensive response to exercise is associated with CAVI, BMI, HbA1c and whether taking statins closely.