CAJ | 학술논문

目的评估慢性心力衰竭患者血清CA125水平,研究血清CA125与B型脑钠肽(BNP)之间的相关性.方法选择住院患者64例,男29例,女35例,年龄55~83(68±15)岁.据纽约心功能(NYHA)分级分为NYHAI~II、NYHAIII与NYHAIV级3组,血清CA125及BNP均在入院24h测定.结果血清CA125水平NYHAI/II级组为(21.6±6.2)U/ml,NYHAIII级组为(35.0±6.7)U/ml,NYHAIV级组为(59.0±24.0)U/ml.NYHAIV级和NYHAIII级组CA125均高于NYHAI~II级组(t=7.3、6.8,均P<0.01).相关分析显示血清CA125与BNP呈正相关(r=0.77,P<0.01).结论血清CA125反映慢性心力衰竭的严重程度,CA125与BNP相关,两者结合可作为心力衰竭的重要诊断依据.
목적평고만성심력쇠갈환자혈청CA125수평,연구혈청CA125여B형뇌납태(BNP)지간적상관성.방법선택주원환자64례,남29례,녀35례,년령55~83(68±15)세.거뉴약심공능(NYHA)분급분위NYHAI~II、NYHAIII여NYHAIV급3조,혈청CA125급BNP균재입원24h측정.결과혈청CA125수평NYHAI/II급조위(21.6±6.2)U/ml,NYHAIII급조위(35.0±6.7)U/ml,NYHAIV급조위(59.0±24.0)U/ml.NYHAIV급화NYHAIII급조CA125균고우NYHAI~II급조(t=7.3、6.8,균P<0.01).상관분석현시혈청CA125여BNP정정상관(r=0.77,P<0.01).결론혈청CA125반영만성심력쇠갈적엄중정도,CA125여BNP상관,량자결합가작위심력쇠갈적중요진단의거.
Objective To assess the correlation of serum carbohydrate antigen 125 (CA125) levels with B-type natri-uretic peptide (BNP) in patients with chronic heart failure. Methods Sixty four hospitalized patients with chronic heart failure were enrol ed, including 29 males and 35 females aged 55-83y (mean 68±15y). The heart functions were classified as NYHA class I/II, III and IV according to New York Heart Association (NYHA). Serum CA125 and plasma BNP was measured within 24h after admission. Results The mean CA125 level was 39.4±21.5 U/ml, that for NYHA I/II, III and IV was 21.6±6.2 U/ml, 35.0± 6.7 U/ml and 59.0±24.0 U/ml, respectively. Serum CA125 levels in patients of NYHA IV and III were significantly higher than that in patients of I/II (t=7.3, 6.8, P<0.01 andP<0.05). Serum CA125 levels were significantly correlated with BNP levels(r=0.77, P<0.01). Conclusion Serum CA125 and BNP levels are correlated with clinical severity of chronic heart failure, which may have diagnostic value.