CAJ | 학술논문

目的:观察大剂量丙种球蛋白治疗小儿重症病毒性脑炎的临床疗效.方法:64例重症病毒性脑炎患儿随机分为治疗组(33例)和对照组(31例).对照组给予解痉,降温,降颅压,改善脑细胞代谢,抗病毒,维持水、电解质的平衡等常规治疗.治疗组在常规治疗基础上应用大剂量丙种球蛋白治疗.观察比较2组病例主要症状、体征消失时间、住院时间及临床治疗效果.结果:治疗组病例治疗后在发热、昏迷、惊厥消失时间以及平均住院时间均明显缩短,治疗组脑电图和脑脊液恢复正常的时间也短于对照组,组间比较差异有统计学意义(P<0畅05);治疗组显效率及总有效率均明显高于对照组(P<0.05).结论:大剂量丙种球蛋白治疗重症病毒性脑炎能迅速改善临床症状,缩短病程.
목적:관찰대제량병충구단백치료소인중증병독성뇌염적림상료효.방법:64례중증병독성뇌염환인수궤분위치료조(33례)화대조조(31례).대조조급여해경,강온,강로압,개선뇌세포대사,항병독,유지수、전해질적평형등상규치료.치료조재상규치료기출상응용대제량병충구단백치료.관찰비교2조병례주요증상、체정소실시간、주원시간급림상치료효과.결과:치료조병례치료후재발열、혼미、량궐소실시간이급평균주원시간균명현축단,치료조뇌전도화뇌척액회복정상적시간야단우대조조,조간비교차이유통계학의의(P<0창05);치료조현효솔급총유효솔균명현고우대조조(P<0.05).결론:대제량병충구단백치료중증병독성뇌염능신속개선림상증상,축단병정.
Objective] To investigate the clinic effect of high dose immunoglobulin in treatment of severe viral encephalitis . [Method] 64 cases of severe viral encephalitis children were randomly divided into the treatment group (33 cases) and Control group (31 cases) .The control group was treated with antispasmodic ,cooling ,reducing intracranial pressure ,improving brain cell metabolism ,antiviral ,maintenance of water ,electrolyte balance and other conventional treatment .The treatment group was administered the routine treatment plus high doses of IVIG treatment .The clinic effects were compared between two groups . [Result] The treatment group of clinical symptoms and signs of recovery time was significantly shortened and the total effective rate was significantly higher than that of compare group .[Conclusion] High-dose gamma globulin treatment of severe viral encephalitis can rapidly improve the clinical symptoms and shorten the course .