浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
ZHEJIANG JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2013年
1期
6-8
,共3页
倪旭伟%张德忠%刘玉梅%叶永玲%徐媚媚
倪旭偉%張德忠%劉玉梅%葉永玲%徐媚媚
예욱위%장덕충%류옥매%협영령%서미미
非糖尿病慢性肾病%游离脂肪酸%超敏C-反应蛋白%肿瘤坏死因子-α%胰岛素抵抗
非糖尿病慢性腎病%遊離脂肪痠%超敏C-反應蛋白%腫瘤壞死因子-α%胰島素牴抗
비당뇨병만성신병%유리지방산%초민C-반응단백%종류배사인자-α%이도소저항
non-diabetic chronic kidney disease%free fatty acid%high sensitive C-reactive protein%tumor ne?crosis factor-α%insulin resistance
目的:观察非糖尿病慢性肾脏病(CKD)患者血清游离脂肪酸(FFA)水平及其与高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、胰岛素抵抗的关系.方法:测定118例非糖尿病CKD患者(非透析治疗80例,血液透析38例)及50名健康人FFA、空腹胰岛素(FINS)、空腹血糖(FPS),同时检测 hs-CRP、TNF-α、血脂等指标,并计算胰岛素敏感指数(ISI)、稳态模型胰岛素抵抗指数(Homa-IR),分析 FFA 与胰岛素抵抗的关系.结果:非糖尿病非透析和透析 CKD 患者血清 FFA、hs-CRP、TNF-α、Homa-IR、TG和LP(α)水平均较健康对照组显著升高(P<0.05或P<0.01),且透析CKD组FFA、hs-CRP、TNF-α、FINS、Homa-IR、TG和 LP(α)水平较非透析CKD组明显升高(P<0.05或 P<0.01);血 FFA 水平与 hs-CRP、TNF-α、FINS、Homa-IR、TG 和 LP(α)呈正相关(P<0.01),与 ISI负相关(P<0.01).结论:非糖尿病CKD患者FFA水平明显升高,且与hs-CRP、TNF-α及胰岛素抵抗密切相关.
目的:觀察非糖尿病慢性腎髒病(CKD)患者血清遊離脂肪痠(FFA)水平及其與高敏C-反應蛋白(hs-CRP)、腫瘤壞死因子(TNF-α)、胰島素牴抗的關繫.方法:測定118例非糖尿病CKD患者(非透析治療80例,血液透析38例)及50名健康人FFA、空腹胰島素(FINS)、空腹血糖(FPS),同時檢測 hs-CRP、TNF-α、血脂等指標,併計算胰島素敏感指數(ISI)、穩態模型胰島素牴抗指數(Homa-IR),分析 FFA 與胰島素牴抗的關繫.結果:非糖尿病非透析和透析 CKD 患者血清 FFA、hs-CRP、TNF-α、Homa-IR、TG和LP(α)水平均較健康對照組顯著升高(P<0.05或P<0.01),且透析CKD組FFA、hs-CRP、TNF-α、FINS、Homa-IR、TG和 LP(α)水平較非透析CKD組明顯升高(P<0.05或 P<0.01);血 FFA 水平與 hs-CRP、TNF-α、FINS、Homa-IR、TG 和 LP(α)呈正相關(P<0.01),與 ISI負相關(P<0.01).結論:非糖尿病CKD患者FFA水平明顯升高,且與hs-CRP、TNF-α及胰島素牴抗密切相關.
목적:관찰비당뇨병만성신장병(CKD)환자혈청유리지방산(FFA)수평급기여고민C-반응단백(hs-CRP)、종류배사인자(TNF-α)、이도소저항적관계.방법:측정118례비당뇨병CKD환자(비투석치료80례,혈액투석38례)급50명건강인FFA、공복이도소(FINS)、공복혈당(FPS),동시검측 hs-CRP、TNF-α、혈지등지표,병계산이도소민감지수(ISI)、은태모형이도소저항지수(Homa-IR),분석 FFA 여이도소저항적관계.결과:비당뇨병비투석화투석 CKD 환자혈청 FFA、hs-CRP、TNF-α、Homa-IR、TG화LP(α)수평균교건강대조조현저승고(P<0.05혹P<0.01),차투석CKD조FFA、hs-CRP、TNF-α、FINS、Homa-IR、TG화 LP(α)수평교비투석CKD조명현승고(P<0.05혹 P<0.01);혈 FFA 수평여 hs-CRP、TNF-α、FINS、Homa-IR、TG 화 LP(α)정정상관(P<0.01),여 ISI부상관(P<0.01).결론:비당뇨병CKD환자FFA수평명현승고,차여hs-CRP、TNF-α급이도소저항밀절상관.
Objective: To investigate the relationship between serum free fatty acid (FFA) and high sensitive C re?active protein (hs-CRP),tumor necrosis factor α (TNF-α),and insulin resistance in patients with non-diabetic chronic kidney disease (CKD). Methods: Serum FFA,fasting insulin (FINS),fasting plasma glucose (FPS), hs-CRP, TNF-α, and the lipid profile were measured and compared between 118 patients with non-diabetic CKD (non-dialytic 80 patients and dialytic 38 patients)and 50 normal controls. Insulin resistance was evaluated by using insulin sensitivity index and homeostasis model assessment-insulin resistance index(Homa-IR). Results:Serum FFA, hs-CRP, TNF-α,Homa-IR, triglyceride and lipoprotein(α) were significantly higher in non-diabetic CKD patients compared to those in normal controls (P<0.05 or P<0.01). The increase of serum FFA,hs-CRP, TNF-α,FINS, Homa-IR,triglyceride and lipoprotein(α) were higher in dialytic patients than those in non-dialyt?ic patients (P<0.05 or P<0.01). In all patients,FFA was positively correlated with hs-CRP, TNF-α, FINS, Homa-IR, triglyceride and lipoprotein(α) but was negatively related to insulin sensitivity index (P<0.01). Conclu?sion: Serum FFA significantly increased in non-diabetic CKD patients and was closely correlated with insulin re?sistance.
