浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
ZHEJIANG JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2013年
1期
9-11
,共3页
胃腺癌%Naked1%MMP-9%免疫组化
胃腺癌%Naked1%MMP-9%免疫組化
위선암%Naked1%MMP-9%면역조화
gastric adenocarcinoma%Naked1%MMP-9%immunohistochemistry
目的:观察胃腺癌组织Naked1和MMP-9蛋白表达特征,探讨两者的关系及临床价值.方法:选择97例胃腺癌术后留取的蜡块作为胃癌组,选择62例正常胃黏膜组织作为正常对照组,应用免疫组织化学技术检测两组中 Naked1和 MMP-9蛋白表达,观察 Naked1和 MMP-9表达与临床病理特征的相关性.结果:胃癌组 Naked1蛋白表达阳性率明显低于正常对照组(P<0.01), MMP-9蛋白表达阳性率明显高于正常对照组(P<0.01).胃癌组 Naked1和 MMP-9蛋白表达与肿瘤的临床分期、淋巴结转移、浸润深度、Ki67表达密切相关(P<0.05或P<0.01);Naked1和MMP-9表达具有负相关性(P<0.05),生存分析显示 Naked1低表达、MMP-9高表达患者预后差.结论:胃腺癌组织 Naked1和 MMP-9呈异常表达,两者对病变的进展具有重要作用,术后检测 Naked1和MMP-9表达可能对判断预后有一定价值.
目的:觀察胃腺癌組織Naked1和MMP-9蛋白錶達特徵,探討兩者的關繫及臨床價值.方法:選擇97例胃腺癌術後留取的蠟塊作為胃癌組,選擇62例正常胃黏膜組織作為正常對照組,應用免疫組織化學技術檢測兩組中 Naked1和 MMP-9蛋白錶達,觀察 Naked1和 MMP-9錶達與臨床病理特徵的相關性.結果:胃癌組 Naked1蛋白錶達暘性率明顯低于正常對照組(P<0.01), MMP-9蛋白錶達暘性率明顯高于正常對照組(P<0.01).胃癌組 Naked1和 MMP-9蛋白錶達與腫瘤的臨床分期、淋巴結轉移、浸潤深度、Ki67錶達密切相關(P<0.05或P<0.01);Naked1和MMP-9錶達具有負相關性(P<0.05),生存分析顯示 Naked1低錶達、MMP-9高錶達患者預後差.結論:胃腺癌組織 Naked1和 MMP-9呈異常錶達,兩者對病變的進展具有重要作用,術後檢測 Naked1和MMP-9錶達可能對判斷預後有一定價值.
목적:관찰위선암조직Naked1화MMP-9단백표체특정,탐토량자적관계급림상개치.방법:선택97례위선암술후류취적사괴작위위암조,선택62례정상위점막조직작위정상대조조,응용면역조직화학기술검측량조중 Naked1화 MMP-9단백표체,관찰 Naked1화 MMP-9표체여림상병리특정적상관성.결과:위암조 Naked1단백표체양성솔명현저우정상대조조(P<0.01), MMP-9단백표체양성솔명현고우정상대조조(P<0.01).위암조 Naked1화 MMP-9단백표체여종류적림상분기、림파결전이、침윤심도、Ki67표체밀절상관(P<0.05혹P<0.01);Naked1화MMP-9표체구유부상관성(P<0.05),생존분석현시 Naked1저표체、MMP-9고표체환자예후차.결론:위선암조직 Naked1화 MMP-9정이상표체,량자대병변적진전구유중요작용,술후검측 Naked1화MMP-9표체가능대판단예후유일정개치.
Objective: To explore the relationship between Naked1 and matrix metalloproteinase 9 (MMP-9) in gas?tric adenocarcinoma and its potential role in prognosis. Methods: Specimens from gastric adenocarcinoma tissue (n=97) and normal gastric tissue (n=62) were harvested. Expression of Naked1 and MMP-9 was determined by using immunohistochemistry. Results: Compared with the normal gastric tissue, Naked1 expression was lower but MMP-9 was higher in the gastric adenocarcinoma tissue. Naked1 and MMP-9 expression was closely related to clinical stage of carcinoma, metastasis,infiltration, and Ki67(P<0.05 or P<0.01). Naked1 was negatively related to MMP-9 (P<0.05). Survival analysis showed that lower expression of Naked1 and higher expression of MMP-9 was associated with poor prognosis. Conclusion: Naked1 is negatively correlated with MMP-9 in gastric adenocar?cinoma and they may play a potential role in determining prognosis of gastric adenocarcinoma patients.
