CAJ | 학술논문

目的观察分析苦参碱联合化疗药物对肺癌的临床疗效.方法选择2010年8月~2012年7月间在我院接受治疗的中晚期肺癌患者90例,随机分成对照组和观察组,各45例,对照组患者仅给予IAP方案(异环磷酰胺、阿霉素和顺铂)化疗,观察组患者在此基础上选择苦参碱联合治疗,比较两组患者的疗效和不良反应.结果观察组的缓解率为77.78%(35/45),显著高于对照组的46.67%(21/45)(P<0.05);观察组患者不良反应的发生率为15.56%(7/45),显著低于对照组的51.11%(23/45)(P<0.05).结论苦参碱联合化疗治疗肺癌患者的临床疗效显著、不良反应发生率低,值得在临床推广.
목적관찰분석고삼감연합화료약물대폐암적림상료효.방법선택2010년8월~2012년7월간재아원접수치료적중만기폐암환자90례,수궤분성대조조화관찰조,각45례,대조조환자부급여IAP방안(이배린선알、아매소화순박)화료,관찰조환자재차기출상선택고삼감연합치료,비교량조환자적료효화불량반응.결과관찰조적완해솔위77.78%(35/45),현저고우대조조적46.67%(21/45)(P<0.05);관찰조환자불량반응적발생솔위15.56%(7/45),현저저우대조조적51.11%(23/45)(P<0.05).결론고삼감연합화료치료폐암환자적림상료효현저、불량반응발생솔저,치득재림상추엄.
objective To investigate and analyze the clinical effects of matrine combined with chemotherapy drugs on lung cancer patients. Methods 90 patients with middle-late lung cancer, who had received treatment in our hospital from August 2010 to July 2012, were chosen as subjects of the experiment. These patients were randomly divided into two groups:control group and observation group, 45 cases in each group. The former was only cured with chemotherapy drugs which are cyclophospha-mide, adriamycin and cisplatin, and the latter with these matrine combined with chemotherapy drugs. Finally, the curative ef-fects and adverse reactions were observed and compared between the two groups. Results The remission rate of the observation group was 77.8%(35/45), significantly higher than that of the control group which was 46.7%(21/45) (P<0.05). In addition, the adverse reaction rate of observation group was 15.56%(7/45), which was significantly lower than that of the control group of 51.11%(23/45) (P<0.05). Conclusion With distinct curative effect and low incidence of adverse reactions on lung cancer pa-tients, the matrine combined with chemotherapy drugs has very important clinical significance.