CAJ | 학술논문

目的:观察吡柔比星联合不同药物的化疗方案治疗晚期乳腺癌的临床疗效及毒副反应.方法:将36例晚期乳腺癌患者根据自身情况,分别应用 THP 为主的联合化疗方案 CTF 或 CTP 进行干预,1年后进行疗效及毒副反应评价.结果:对所有患者均进行电话随访 1年,随诊率100.00%,36例患者中存活34例,存活率94.44%,有效率41.18%.存活患者的平均缓解期分别为5.7个月,中位生存期分别为9.9个月.所有患者经过3个月同期化疗结束后,出现消化道副反应者最多,其次为不同程度的发热、明显腹痛腹泻.结论:以吡柔比星为主的联合不同药物的化疗方案在晚期乳腺癌的治疗中,具有疗效佳、安全性高的特点,具临床推广价值.
목적:관찰필유비성연합불동약물적화료방안치료만기유선암적림상료효급독부반응.방법:장36례만기유선암환자근거자신정황,분별응용 THP 위주적연합화료방안 CTF 혹 CTP 진행간예,1년후진행료효급독부반응평개.결과:대소유환자균진행전화수방 1년,수진솔100.00%,36례환자중존활34례,존활솔94.44%,유효솔41.18%.존활환자적평균완해기분별위5.7개월,중위생존기분별위9.9개월.소유환자경과3개월동기화료결속후,출현소화도부반응자최다,기차위불동정도적발열、명현복통복사.결론:이필유비성위주적연합불동약물적화료방안재만기유선암적치료중,구유료효가、안전성고적특점,구림상추엄개치.
Objective:To evaluate efficacy and toxicity of THP-containing regimen in the treatment of advanced breast Cancer.Methods:36 cases of advanced breast cancer patients based on their own conditions,respectively,the application of THP based combination chemotherapy in CTF or CTP intervention, 1 years after curative effect and adverse reaction evaluation.Results:All patients underwent telephone follow-up of 1 years,the follow-up rate was 100.00%,in 36 patients,34 cases survived,the survival rate was 94.44%,with an efficiency of 41.18%.Survival in patients with average remission 5.7 months respectively, the median survival time was 9.9 months.In all patients after three months earlier after the completion of chemotherapy,gastrointestinal side effects were the most, followed by varying degrees of fever,abdominal pain and diarrhea are obvious.Conclusion:THP containing regimen is an active regimen for patients with advanced breast cancer with low toxicity and worthy of being widely used in the clinical.