中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2013年
3期
51-52
,共2页
肿瘤标志物%卵巢癌
腫瘤標誌物%卵巢癌
종류표지물%란소암
Tumor markers%Ovarian cancer
目的:研究 CA125、CA153、CA199在卵巢癌血清、腹水或腹腔冲洗液中的表达情况,探讨其在卵巢癌及其转移早期诊断中的作用.方法:采用电化学发光法检测卵巢癌患者血清、腹水或腹腔冲洗液和正常对照血清、腹腔冲洗液中 CA125、CA153、CA199的表达情况.结果:(1)卵巢癌血清、腹水或腹腔冲洗液中及淋巴结中的 CA125、CA153、CA199表达水平明显增高,与正常对照组差异显著(P<0.01);(2)Logistic 回归分析显示:血清、腹水或腹腔冲洗液中的 CA125、CA153、CA199表达情况对卵巢癌及其微转移早期诊断均有一定的判别意义,其中血清、腹水或腹腔冲洗液中的 CA125的判别意义最大;(3)随着卵巢癌手术病理分期期别的增加,CA125表达率也显著升高(P<0.01),提示与卵巢癌侵袭、转移的恶性生物学行为有关.结论:通过测定患者血清、腹水或腹腔冲洗液中 CA125、CA153、CA199表达情况,对卵巢癌及其转移早期诊断有较好的诊断意义.
目的:研究 CA125、CA153、CA199在卵巢癌血清、腹水或腹腔遲洗液中的錶達情況,探討其在卵巢癌及其轉移早期診斷中的作用.方法:採用電化學髮光法檢測卵巢癌患者血清、腹水或腹腔遲洗液和正常對照血清、腹腔遲洗液中 CA125、CA153、CA199的錶達情況.結果:(1)卵巢癌血清、腹水或腹腔遲洗液中及淋巴結中的 CA125、CA153、CA199錶達水平明顯增高,與正常對照組差異顯著(P<0.01);(2)Logistic 迴歸分析顯示:血清、腹水或腹腔遲洗液中的 CA125、CA153、CA199錶達情況對卵巢癌及其微轉移早期診斷均有一定的判彆意義,其中血清、腹水或腹腔遲洗液中的 CA125的判彆意義最大;(3)隨著卵巢癌手術病理分期期彆的增加,CA125錶達率也顯著升高(P<0.01),提示與卵巢癌侵襲、轉移的噁性生物學行為有關.結論:通過測定患者血清、腹水或腹腔遲洗液中 CA125、CA153、CA199錶達情況,對卵巢癌及其轉移早期診斷有較好的診斷意義.
목적:연구 CA125、CA153、CA199재란소암혈청、복수혹복강충세액중적표체정황,탐토기재란소암급기전이조기진단중적작용.방법:채용전화학발광법검측란소암환자혈청、복수혹복강충세액화정상대조혈청、복강충세액중 CA125、CA153、CA199적표체정황.결과:(1)란소암혈청、복수혹복강충세액중급림파결중적 CA125、CA153、CA199표체수평명현증고,여정상대조조차이현저(P<0.01);(2)Logistic 회귀분석현시:혈청、복수혹복강충세액중적 CA125、CA153、CA199표체정황대란소암급기미전이조기진단균유일정적판별의의,기중혈청、복수혹복강충세액중적 CA125적판별의의최대;(3)수착란소암수술병리분기기별적증가,CA125표체솔야현저승고(P<0.01),제시여란소암침습、전이적악성생물학행위유관.결론:통과측정환자혈청、복수혹복강충세액중 CA125、CA153、CA199표체정황,대란소암급기전이조기진단유교호적진단의의.
Objective:To study the expression of CA125,CA153 and CA199 of serum,ascites and peritoneal washing liquid,explore the value of three tumor markers in ovarian cancer and the early diagnosis of its metastasis.Methods:Electrochemiluminescence method was used to respectively detect the levels of CA125,CA153 and CA199 of serum,ascites and peritoneal washing liquid both in patients with ovarian cancer and the normal control group.Results:(1)The levels of CA125,CA153 and CA199 of serum,ascites and peritoneal washing liquid in patients with ovarian cancer were significantly higher than those in normal control group(P<0.01).(2)The regression analysis of Logistic showed that the expression of CA125,CA153 and CA199 of serum,ascites and peritoneal washing liquid all had some distinguish significance to diagnose ovarian cancer and the early diagnosis of its metastasis,especially CA125.(3)The rate of CA125 expression was obviously raised up,following pathological stages of ovarian cancer operation increased.It prompted the rate was related with the malignant biological behaviour of invasion and metastasis of ovarian cancer.Conclusion:It is significant to diagnose ovarian cancer and early diagnosis of its metastasis by detecting CA125, CA153 and CA199 of serum,ascites and peritoneal washing liquid in patients.
