CAJ | 학술논문

目的:评价七味化纤汤联合α干扰素治疗瘀血阻络证慢性乙型肝炎的疗效及其对患者肝纤维化瞬时弹性(FibroScan)测定值、α干扰素副作用的影响.资料与方法:观察对照组(α干扰素)76例,治疗组(α干扰素+七味化纤汤)78例治疗前后患者肝功复常率、HBV DNA 转阴率、HBeAg 血清学转换转换率及肝纤维化瞬时弹性测定值的变化.综合评价七味化纤汤联合α干扰素对瘀血阻络证慢性乙型肝炎患者疗效、肝纤维化程度、α干扰素副作用的影响.结论:七味化纤汤联合α干扰素抗病毒治疗能提高慢性乙型肝炎的抗病毒疗效(P<0.05),改善肝纤维化的程度(P<0.05),减少干扰素副作用(P<0.05).
목적:평개칠미화섬탕연합α간우소치료어혈조락증만성을형간염적료효급기대환자간섬유화순시탄성(FibroScan)측정치、α간우소부작용적영향.자료여방법:관찰대조조(α간우소)76례,치료조(α간우소+칠미화섬탕)78례치료전후환자간공복상솔、HBV DNA 전음솔、HBeAg 혈청학전환전환솔급간섬유화순시탄성측정치적변화.종합평개칠미화섬탕연합α간우소대어혈조락증만성을형간염환자료효、간섬유화정도、α간우소부작용적영향.결론:칠미화섬탕연합α간우소항병독치료능제고만성을형간염적항병독료효(P<0.05),개선간섬유화적정도(P<0.05),감소간우소부작용(P<0.05).
Objective: To assess the clinical effects of the Qiwei Huaxian decoction combined with alpha-interferon in chronic hepatitis B and the influence on the values of transient fibro scan and side effects of interferon-alpha of liver fibrosis patients. Materials and Methods: All the patients were randomly divided into two groups, 76 cases in the control group and 78 cases in the treatment group. The control group was treated with interferon-alpha only, while the treatment group was treated with interferon-alpha and the Qiwei Huaxian decoction. The recovery rate of liver function, the turning negative rate of HBV DNA, the conversion rate of HBeAg serology and the variation of the value of the transient fibro scan of the control group and the treatment group were observed. The clinical effect, the degree of liver fibrosis and the side effect of interferon-alpha were evaluated. Conclusion: The Qiwei Huaxian decoction combined with interferon-alpha could improve the anti-virus effect in chronic hepatitis B, relieve the degree of liver fibrosis (P<0.05) and reduce the side effects of interferon (P<0.05).