CAJ | 학술논문

目的:探讨生脉散调节慢性肝衰竭大鼠内毒素血症的作用机理.方法:CCL4腹腔注射法建立大鼠慢性肝衰竭模型,在此基础上以 LPS 攻击以建立慢性肝衰竭内毒素血症模型,用生脉散治疗并与对照组比较.取造模后2h 时间点,检测大鼠血清 LPS(内毒素)与细胞因子如 TNF-a,IL-6,ICAM-1水平.结果:2h 后生脉散可减低慢性肝衰竭内毒素血症大鼠血清 LPS、TNFα、IL-6,ICAM-1水平,差异有统计学意义(P<0.001).结论:慢性肝衰竭状态下,可存在不同程度的内毒素血症,并引起细胞因子水平变化,生脉散通过调节内毒素及细胞因子水平是其起到治疗作用的重要原因.
목적:탐토생맥산조절만성간쇠갈대서내독소혈증적작용궤리.방법:CCL4복강주사법건립대서만성간쇠갈모형,재차기출상이 LPS 공격이건립만성간쇠갈내독소혈증모형,용생맥산치료병여대조조비교.취조모후2h 시간점,검측대서혈청 LPS(내독소)여세포인자여 TNF-a,IL-6,ICAM-1수평.결과:2h 후생맥산가감저만성간쇠갈내독소혈증대서혈청 LPS、TNFα、IL-6,ICAM-1수평,차이유통계학의의(P<0.001).결론:만성간쇠갈상태하,가존재불동정도적내독소혈증,병인기세포인자수평변화,생맥산통과조절내독소급세포인자수평시기기도치료작용적중요원인.
Objective: To investigate the mechanism of Shengmai powder in regulating rat endoxemia from chronic hepatic failure. Methods: Chronic hepatic failure rat model was established by CCl4 intraperitoneal injection method. Based on that, LPS was given to establish chronic hepatic failure endoxemia. The effect of Shenmai powder was investigated by comparing with the control group. The contents of LPS and cytokines including TNF-α,IL-6, ICAM-1 in serum were detected 2h after the model was established. Results:Shengmai powder decreased the contents of LPS and cytokines including TNF-α,IL-6, ICAM-1 in serum significantly (P<0.001). Conclusion: Shengmai powder could significantly regulate the contents of LPS and cytokines in rats with chronic hepatic failure endoxemia.