CAJ | 학술논문

目的探讨5-氟尿嘧啶(5-Fu)纳米炭示踪剂在中低位直肠癌手术中的应用价值.方法选取中低位直肠癌手术患者53例,随机分为观察组32例和对照组21例.观察组术前应用5-氟尿嘧啶纳米炭淋巴示踪剂;对照组常规行直肠癌根治术.比较两组病理标本所检出的淋巴结数量、转移淋巴结癌细胞凋亡指数、术后淋巴化疗所引起的毒副作用.结果观察组平均淋巴结数量(16.23±5.50)个,明显高于对照组的(11.28±6.35)个(P<0.05).观察组检出微小淋巴结(直径≤2 mm)的比例为27.98%(141/504),对照组微小淋巴结的比例为18.17%(43/238),观察组检获微小淋巴结明显多于对照组(P<0.05).观察组淋巴结转移细胞凋亡指数为(33.58±3.27)%;对照组转移淋巴结中细胞凋亡指数为(6.11±2.52)%.观察组转移淋巴结中细胞凋亡率明显高于对照组,两组间差异有统计学意义(P<0.05).没有发现由于使用5-氟尿嘧啶纳米炭淋巴示踪剂所引起的毒副作用.结论使用5-氟尿嘧啶纳米炭淋巴示踪剂有利于中低位直肠癌的手术及综合治疗.
목적탐토5-불뇨밀정(5-Fu)납미탄시종제재중저위직장암수술중적응용개치.방법선취중저위직장암수술환자53례,수궤분위관찰조32례화대조조21례.관찰조술전응용5-불뇨밀정납미탄림파시종제;대조조상규행직장암근치술.비교량조병리표본소검출적림파결수량、전이림파결암세포조망지수、술후림파화료소인기적독부작용.결과관찰조평균림파결수량(16.23±5.50)개,명현고우대조조적(11.28±6.35)개(P<0.05).관찰조검출미소림파결(직경≤2 mm)적비례위27.98%(141/504),대조조미소림파결적비례위18.17%(43/238),관찰조검획미소림파결명현다우대조조(P<0.05).관찰조림파결전이세포조망지수위(33.58±3.27)%;대조조전이림파결중세포조망지수위(6.11±2.52)%.관찰조전이림파결중세포조망솔명현고우대조조,량조간차이유통계학의의(P<0.05).몰유발현유우사용5-불뇨밀정납미탄림파시종제소인기적독부작용.결론사용5-불뇨밀정납미탄림파시종제유리우중저위직장암적수술급종합치료.
Objective To evaluate the outcomes of activated carbon nanoparticles carrying 5-fluorouracil (5-Fu) in radical operation of middle-low rectal cancer. Methods Fifty-three patients with middle-low rectal cancer were enrolled and randomLy divided into two groups in this study . The activated carbon nanoparticles carrying 5-Fu were injected around the tumor regions before surgical resection in 32 patients (group A), Which were not in other 21 patients underwent the standard radical operation as the control( group B). The black-stained sentinel lymph nodes were observed. The number of lymph nodes in pathologic samples, the ratio of tiny lymph node (diameter 2 mm or less) and the apoptosis index of cancer cells in metastatic lymph nodes were compared between the two groups. Results The mean number of lymph nodes in pathological samples was significantly higher in group A than that in group B (16.23±5.50 and 11.28±6.35,P<0.05). The ratio of tiny lymph node in group A was more than that in group B (27.98% vs 18.17%,P<0.05). The apoptosis index of cancer cells in metastatic lymph nodes was significantly higher in group A than that in group B( (33.58±3.27)%and (6.11±2.52)%,P<0.05). The side effects were not found in group A. Conclusion Application of activated carbon nanoparticles carrying 5-Fu may be an useful adjuvant therapy in radical operation of the patients with middle-low rectal cancer.