CAJ | 학술논문

药物共晶是一种新的药物晶型,对于一个给定的活性药物成分,通过形成共晶一方面可以改善药物的理化性质,提高临床药效,另一方面可以增加药物的结晶形式,这在新药研发中具有很大的应用潜力.文章综述性地介绍药物共晶近年来的主要制备方法和表征方法,为制备新的药物共晶提供参考.
약물공정시일충신적약물정형,대우일개급정적활성약물성분,통과형성공정일방면가이개선약물적이화성질,제고림상약효,령일방면가이증가약물적결정형식,저재신약연발중구유흔대적응용잠력.문장종술성지개소약물공정근년래적주요제비방법화표정방법,위제비신적약물공정제공삼고.
Drug eutectic is a kind of new drug polymorphs, for a given active pharmaceutical ingredients, through the formation of eutectic hand can improve the physicochemical properties of the drug, to improve the clinical efficacy, on the one hand can increase the drug to the crystalline form, which in the new drug research and development has great potential application. The paper introduced drug eutectic in recent years the main preparation methods and analyzed methods, for the preparation of new pharmaceutical reference.