CAJ | 학술논문

高迁移率族(HMG)蛋白是一种广泛存在于真核生物染色质内的非组蛋白,因其相对分子质量小,在聚丙稀酰胺凝胶电泳时迁移速度快而得名.高迁移率族蛋白N家族(HMGN)是新发现的因子,它在DNA损伤的染色质改变中起着重要作用, DNA损伤是肿瘤形成和发展的主要因素,而DNA损伤主要源自紫外线和电离辐射.本文将对HMGN在抗肿瘤方面的作用作一综述.
고천이솔족(HMG)단백시일충엄범존재우진핵생물염색질내적비조단백,인기상대분자질량소,재취병희선알응효전영시천이속도쾌이득명.고천이솔족단백N가족(HMGN)시신발현적인자,타재DNA손상적염색질개변중기착중요작용, DNA손상시종류형성화발전적주요인소,이DNA손상주요원자자외선화전리복사.본문장대HMGN재항종류방면적작용작일종술.
@@@@High mobility group(HMG) protein is a non-histone protein that is widely present in eukaryotes chromatin. HMG wins its name because of its small molecular weight and rapid migration in polyacrylamide gel electrophoresis. DNA damage originated from both ultra violet light and ionizing irradiation. High mobility group N (HMGN) protein is an emerging factor that is important for chromatin alterations in response to DNA damage. DNA lesions threaten the integrity of the genome and are a major factor in cancer formation and progression. The role of HMGN in anti-tumor will be discussed.