CAJ | 학술논문

患者女性,85岁,因房颤长期服用华法林,国际标准化比值(INR)1.6-2.5.患者因咽痛服用头孢氨苄片3d,停用2d后INR升至11.72,伴右上臂片状瘀斑.次日停用华法林,给予静脉滴注10mg维生素K1,INR降至2.6.2d后重启华法林治疗,INR1.6-2.5.应用华法林时如增加合并用药,要密切监测INR及出血情况,重视华法林的药物相互作用.患者教育对华法林的用药安全十分重要.
환자녀성,85세,인방전장기복용화법림,국제표준화비치(INR)1.6-2.5.환자인인통복용두포안변편3d,정용2d후INR승지11.72,반우상비편상어반.차일정용화법림,급여정맥적주10mg유생소K1,INR강지2.6.2d후중계화법림치료,INR1.6-2.5.응용화법림시여증가합병용약,요밀절감측INR급출혈정황,중시화법림적약물상호작용.환자교육대화법림적용약안전십분중요.
An 85-year old woman had a history of long-term oral warfarin for atrial fibril ation, with INR range between 1.6 and 2.5. The patient had taken cephalexin for 3 days due to pharyngitis, INR increased to 11.72 two days afer withdrawl of cephalexin. Ecchymosis occurred at the right upper-arm. Warfarin was withdrawn next day and INR decreased to 2.6 after intravenous vitamin K1 (10mg), Warfarin was restarted and INR was between 1.6 and 2.5. INR and bleeding should be monitored more intensely if increase in drug combination. Interaction of warfarin with other drugs should be given more attention. Patient’s education is very important for safety of warfarin use.