CAJ | 학술논문

目的:优化薄膜蒸发法制备吲哚美辛醇质体的工艺参数.方法:采用正交试验设计,考察了药物的量、磷脂用量、乙醇浓度、搅拌时间等影响因素,并以包封率作为评价指标,利用SPSS11.5对结果进行分析,筛选出最佳工艺.结果:最佳工艺为取吲哚美辛0.15g,加入0.5g磷脂,用氯仿10ml溶解,蒸干,使形成一个均匀的薄膜,加入50ml缓冲液(30%乙醇-pH5.3磷酸缓冲液),搅拌30min,即得.平均包封率为75.06%.结论:该薄膜蒸发法制备醇质体的工艺稳定可行.
목적:우화박막증발법제비신타미신순질체적공예삼수.방법:채용정교시험설계,고찰료약물적량、린지용량、을순농도、교반시간등영향인소,병이포봉솔작위평개지표,이용SPSS11.5대결과진행분석,사선출최가공예.결과:최가공예위취신타미신0.15g,가입0.5g린지,용록방10ml용해,증간,사형성일개균균적박막,가입50ml완충액(30%을순-pH5.3린산완충액),교반30min,즉득.평균포봉솔위75.06%.결론:해박막증발법제비순질체적공예은정가행.
Objective: To optimize the processing technology of indomethacin ehtosmoes. Methods: The drug dosage, phospholipid dosage, alcohol concentration, stirring time and some other influencing factors were investi-gated by orthogonal experimental design. Encapsulation rate was token as the evaluation index with SPSS11.5 as the statistical analyzing software. Results: The optimum processing technology was: indomethacin 0.15g and phospholipids 0.5g dissolved with chloroform 10ml,and evaporated to form a film, 40ml buffer (30% ethanol-pH5.3 phosphate buffer was added), and stirring for 30min. The average encapsulation rate was 75.06%. Conclu-sion:The processing technology is stable and feasible.