CAJ | 학술논문

目的:调查了解引起肝损害的药物品种,给药途径,药物性肝损害的临床分类,患者性别及年龄,临床表现及治疗措施等情况,以期为临床用药提供参考.方法:以“肝损害”“不良反应”为关键词检索相关数据库2001年至2011年文献,从中筛选出3344例药物致肝损害病例进行回顾性分析和探讨.结果:本次检索共命中相关文献136篇,其中综合病例报道37篇,个案报道99篇,累计病例3344例.药物性肝损害的最常见给药途径是口服给药,为77.96%.临床表现多为黄疸,乏力,消化系统症状等非特异性症状.肝损害的临床分类中以肝细胞损害型最为常见.药物引起肝损害的病例数前五位为抗结核药、中药及中成药、抗生素、抗肿瘤药、解热镇痛抗炎药.结论:引起肝损害的药物种类繁多,由于药物性肝损害的临床表现无特异性,易误诊及漏诊,应引起临床高度重视.
목적:조사료해인기간손해적약물품충,급약도경,약물성간손해적림상분류,환자성별급년령,림상표현급치료조시등정황,이기위림상용약제공삼고.방법:이“간손해”“불량반응”위관건사검색상관수거고2001년지2011년문헌,종중사선출3344례약물치간손해병례진행회고성분석화탐토.결과:본차검색공명중상관문헌136편,기중종합병례보도37편,개안보도99편,루계병례3344례.약물성간손해적최상견급약도경시구복급약,위77.96%.림상표현다위황달,핍력,소화계통증상등비특이성증상.간손해적림상분류중이간세포손해형최위상견.약물인기간손해적병례수전오위위항결핵약、중약급중성약、항생소、항종류약、해열진통항염약.결론:인기간손해적약물충류번다,유우약물성간손해적림상표현무특이성,역오진급루진,응인기림상고도중시.
Objective:To investigate drug-induced hepatic injury for promoting clinical rational use of drugs. Methods: With “hepatic injury”and “adverse reactions” as keywords, drug-induced hepatic injury cases were retrieved from relevant databases from 2001 to 2011, analyzed and discussed. Results: 136 papers including 37 Summary reports, and 99 individual case reports with a total of 3344 cases of drug-induced hepatic injury were retrieved. 77.96% cases were via oral administration.Most clinical manifestations were jaundice, lassitude, and nonspecific digestive syste system. Liver cell damage was the most common type.The top five drugs that caused liver injury were TB drugs, traditional Chinese medicine, antibiotics, antineoplastics,antipyretic analgesics and anti-inflammatory drugs. Conclusion: A great variety of drugs can induce liver injury.Because of its non-specific clinical manifestation,and the possibility of its misdiagnosis and missed diagnosis,great importance should be at-tached to the monitoring and rational use of the related drugs.