CAJ | 학술논문

目的:比较英夫利西单抗(infliximab,IFX)联合甲氨蝶呤(methotrexate,MTX)与来氟米特(LEF)及甲氨蝶呤(MTX)治疗类风湿关节炎(rheumatoid arthritis,RA)的疗效和不良反应.方法:将54例类风湿关节炎患者按随机数字表法分为两组:治疗组31例,治疗组在每周口服甲氨蝶呤(MTX)10~15 mg基础上联合应用英夫利西单抗,在第0、2、6周接受3mg/kg的英夫利西单抗静脉滴注;对照组23例口服相同剂量的MTX,联合应用LEF.疗程均为12周,观察评价关节肿胀压痛数,疼痛视觉模拟评分(Visual Analogue Scale/Score,简称VAS)及疲乏VAS评分,同时监测患者血沉(ESR)、类风湿因子(RF)、肝肾功、血尿常规等指标.结果:在疗程第6周和12周,治疗组患者关节肿胀压痛数、患者VAS评分及血沉改善与对照组比较,差异有统计学意义;DAS28评分比较发现,治疗组患者达到低疾病活动度比例高于对照组,差异有统计学意义(P<0.05).结论:英夫利西单抗联合甲氨蝶呤治疗类风湿关节炎疗效优于来氟米特与甲氨蝶呤两药联合.
목적:비교영부리서단항(infliximab,IFX)연합갑안접령(methotrexate,MTX)여래불미특(LEF)급갑안접령(MTX)치료류풍습관절염(rheumatoid arthritis,RA)적료효화불량반응.방법:장54례류풍습관절염환자안수궤수자표법분위량조:치료조31례,치료조재매주구복갑안접령(MTX)10~15 mg기출상연합응용영부리서단항,재제0、2、6주접수3mg/kg적영부리서단항정맥적주;대조조23례구복상동제량적MTX,연합응용LEF.료정균위12주,관찰평개관절종창압통수,동통시각모의평분(Visual Analogue Scale/Score,간칭VAS)급피핍VAS평분,동시감측환자혈침(ESR)、류풍습인자(RF)、간신공、혈뇨상규등지표.결과:재료정제6주화12주,치료조환자관절종창압통수、환자VAS평분급혈침개선여대조조비교,차이유통계학의의;DAS28평분비교발현,치료조환자체도저질병활동도비례고우대조조,차이유통계학의의(P<0.05).결론:영부리서단항연합갑안접령치료류풍습관절염료효우우래불미특여갑안접령량약연합.
@@@@Objective: To compare the efficacy and safety between infliximab (IFX ) combined with methotrexate (MTX) and leflunomide combined with MTX on the treatment of rheumatoid arthritis. Methods: 54 cases of RA in two groups were retrospectively analyzed. In infliximab treatment group, 31 patients were treated with infliximab 3mg/kg on the 0, 2 and 6 week, combined with methotrexate (MTX)10~15 mg per week. In the comparison group, 23 patients received the same dosage of MTX combined with leflunomide (LEF). The treatment course was 12 weeks. The indexes of efficacy assessment included the counts of joint tenderness,and joint swollen, patients’ full-scale assessment with visual analogue scale,and erythrocyte sedimentation rate (ESR);at the same time adverse events were registered. Results: After 6 and 12 weeks’ treatment,there were significant differences (P<0.05)between the two groups,and more patients in the experiment group ameliorated. DAS28 sug gested that the efficacy in the experiment group was better than that in the comparison one. No significant difference was found in adverse events between the two groups. Conclusion:The therapeutic efficacy of MTX combined with infliximab(IFX) on the treatment of rheumatoid arthritis is much better than that of LEF combined with MTX.