CAJ | 학술논문

目的:研究益赛普联合甲氨蝶呤治疗类风湿关节炎(RA)的临床疗效.方法:联合治疗组38例RA患者口服甲氨蝶呤15mg/周,同时皮下注射益赛普25mg/次,每周2次;对照组患者40例服相同剂量的甲氨蝶呤.治疗3个月后对两组的临床症状及实验室指标改善情况进行评价.结果:两组在缓解关节疼痛、减轻关节肿胀等方面均有良好的效果,联合治疗组优于对照组;两组治疗后血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)均明显降低,且联合治疗组优于对照组.结论:益赛普联合甲氨蝶呤治疗RA疗效确切,且明显优于单用甲氨蝶呤.
목적:연구익새보연합갑안접령치료류풍습관절염(RA)적림상료효.방법:연합치료조38례RA환자구복갑안접령15mg/주,동시피하주사익새보25mg/차,매주2차;대조조환자40례복상동제량적갑안접령.치료3개월후대량조적림상증상급실험실지표개선정황진행평개.결과:량조재완해관절동통、감경관절종창등방면균유량호적효과,연합치료조우우대조조;량조치료후혈침(ESR)、C반응단백(CRP)、류풍습인자(RF)균명현강저,차연합치료조우우대조조.결론:익새보연합갑안접령치료RA료효학절,차명현우우단용갑안접령.
Objective:To study the clinical efficacy of etanercept combined with methotrexate on patients with rheumatoid arthritis. Methods: The combination group (38 cases) was treated by oral methotrexate 15mg once a week plus subcutaneous injection of etanercept 25mg twice a week; the control group (40 cases) was treated by methotrexate only. After 3 months of treatment, the clinical symptoms and laboratory parameters of the two groups were evaluated. Results: Both groups had good effects on pain relief and reduction of swelling of joints, but the combination group showed better effects than the control group(P<0.05).The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),and rheumatoid factor (RF) were significantly more reduced in the combination group than in the control group(P<0.05). Conclusion: The combination of etanercept and methotrexate in the treatment of rheumatoid arthritis is significantly superior to methotrexate alone.