CAJ | 학술논문

探讨了以低聚果糖、菊粉、富硒酵母为主要原料所研制而成的功能牛奶的免疫调节作用.实验采用250只体重为(20±3)g的清洁的ICR小鼠,随机分为5组,每组50只.每组再分成空白对照组、牛奶对照组和低(0.4 mL/kg·bw)、中(0.8 mL/kg·bw)、高(2.5 mL/kg·bw)5个剂量组,并于给药30 d后,分别从细胞免疫、体液免疫、单核-巨噬细胞功能及NK细胞活性4个方面,对功能牛奶的作用进行了研究.结果表明,不同剂量的功能牛奶对小鼠的体重差异无显著影响;中剂量组对于提高巨噬细胞吞噬能力有显著作用;高剂量组对提高小鼠脾淋巴细胞转化、增强小鼠迟发型变态反应、增加抗体生成和抗体体积、以及提高小鼠碳廓清能力和巨噬细胞吞噬能力,提高NK细胞活性均有显著作用.依据《保健食品检验与评价技术规范-2003》结果判定,功能牛奶具有增强免疫力的作用.
탐토료이저취과당、국분、부서효모위주요원료소연제이성적공능우내적면역조절작용.실험채용250지체중위(20±3)g적청길적ICR소서,수궤분위5조,매조50지.매조재분성공백대조조、우내대조조화저(0.4 mL/kg·bw)、중(0.8 mL/kg·bw)、고(2.5 mL/kg·bw)5개제량조,병우급약30 d후,분별종세포면역、체액면역、단핵-거서세포공능급NK세포활성4개방면,대공능우내적작용진행료연구.결과표명,불동제량적공능우내대소서적체중차이무현저영향;중제량조대우제고거서세포탄서능력유현저작용;고제량조대제고소서비림파세포전화、증강소서지발형변태반응、증가항체생성화항체체적、이급제고소서탄곽청능력화거서세포탄서능력,제고NK세포활성균유현저작용.의거《보건식품검험여평개기술규범-2003》결과판정,공능우내구유증강면역력적작용.
@@@@The immunomodulatory effects of Functional Milk including FOS (Fructo oligosaccharide), inulin , Selenium enriched yeast in mice were explored .Two hundred and fifty mice, weight in the range of 17 and 23 gram, were divided into five treatment groups and fed at five dose. The dose groups were normal control group, milk control group, low dose group (0.4 mL/kg·bw), middle dose group (0.8 mL/kg·bw) and high dose group (2.5 mL/kg·bw) respectively. Cellular immunity, humoral immunity, monocyte - macrophage cell function and activity of natural-killer (NK) cells were investigated to verify immune function of functional milk. The results showed that no significant effect was observed on weight gain. Compared with the normal and milk control group, the phagocytic capacity of macrophage in medium dose group was significantly different. The activity of lymphocyte transformation , delayed type hypersensitivity (DTH ), antibody formation cell and haemolysis value, clearance capacity of carbon and phagocytic capacity of macrophages, activity of NK cells in high dose group were highly significantly different. According to '2003 checking and appraising a technical code on health-care food' decides, functional milk can enhance the immune function in mice.