CAJ | 학술논문

组织构建%骨组织构建%组织构建与中医药%桡骨骨折%淫羊藿苷%辛伐他汀%骨形态发生蛋白2%剂量比%骨折愈合%骨折二期愈合模型組織構建%骨組織構建%組織構建與中醫藥%橈骨骨摺%淫羊藿苷%辛伐他汀%骨形態髮生蛋白2%劑量比%骨摺愈閤%骨摺二期愈閤模型
조직구건%골조직구건%조직구건여중의약%뇨골골절%음양곽감%신벌타정%골형태발생단백2%제량비%골절유합%골절이기유합모형
tissue construction%bone tissue construction%tissue construction and traditional Chinese medicine%radial fractures%icarin%simvastatin%bone morphogenetic protein-2%dosage ratio%fracture healing%fracture healing model at the second stage

背景:淫羊藿苷与辛伐他汀单独或联合应用均可以促进骨折愈合,联合应用的最佳剂量比缺乏实验依据.目的:观察不同剂量比淫羊藿苷与辛伐他汀对家兔骨折愈合的影响. 方法:将45只健康家兔建立双侧桡骨骨折模型,随机等分为模型组、骨形态发生蛋白2组和淫羊藿苷∶辛伐他汀3∶1,1∶1,1∶3组.模型组、骨形态发生蛋白2组给予生理盐水灌胃,淫羊藿苷∶辛伐他汀3∶1,1∶1,1∶3组给予淫羊藿苷溶液15 mL/(kg?d)和辛伐他汀溶液5 mL/(kg?d),淫羊藿苷溶液10 mL/(kg?d)和辛伐他汀溶液10 mL/(kg?d),淫羊藿苷溶液5 mL/(kg?d)和辛伐他汀溶液15 mL/(kg?d)灌胃.模型组和淫羊藿苷:辛伐他汀3∶1,1∶1,1∶3组骨折局部注射生理盐水,骨形态发生蛋白2组骨折局部注射骨形态发生蛋白2溶液.灌胃连续6周,骨折局部注射连续2周. 结果与结论:在骨痂生长、改建和髓腔再通、骨密度和骨折部位组织形态方面,骨形态发生蛋白2、淫羊藿苷:辛伐他汀1∶1组最好,淫羊藿苷:辛伐他汀3∶1,1∶3组居中,模型组最差.提示不同剂量比淫羊藿苷和辛伐他汀联合应用均可促进家兔桡骨骨折愈合,当剂量比为1∶1时,促进作用更显著.
배경:음양곽감여신벌타정단독혹연합응용균가이촉진골절유합,연합응용적최가제량비결핍실험의거.목적:관찰불동제량비음양곽감여신벌타정대가토골절유합적영향. 방법:장45지건강가토건립쌍측뇨골골절모형,수궤등분위모형조、골형태발생단백2조화음양곽감∶신벌타정3∶1,1∶1,1∶3조.모형조、골형태발생단백2조급여생리염수관위,음양곽감∶신벌타정3∶1,1∶1,1∶3조급여음양곽감용액15 mL/(kg?d)화신벌타정용액5 mL/(kg?d),음양곽감용액10 mL/(kg?d)화신벌타정용액10 mL/(kg?d),음양곽감용액5 mL/(kg?d)화신벌타정용액15 mL/(kg?d)관위.모형조화음양곽감:신벌타정3∶1,1∶1,1∶3조골절국부주사생리염수,골형태발생단백2조골절국부주사골형태발생단백2용액.관위련속6주,골절국부주사련속2주. 결과여결론:재골가생장、개건화수강재통、골밀도화골절부위조직형태방면,골형태발생단백2、음양곽감:신벌타정1∶1조최호,음양곽감:신벌타정3∶1,1∶3조거중,모형조최차.제시불동제량비음양곽감화신벌타정연합응용균가촉진가토뇨골골절유합,당제량비위1∶1시,촉진작용경현저.
@@@@BACKGROUND:Icari n and simvastatin alone or in combination can promote the radial fracture healing of rabbits. But the best dosage ratio is stil lack of basis. @@@@OBJECTIVE:To investigate the effect of icari n and simvastatin with different dosage ratios on rabbits’ radial fracture healing. @@@@METHODS:Forty-five healthy rabbits were enrol ed to prepare bilateral radial fracture models, and then randomly divided into five groups:model group;bone morphogenetic protein-2 control group;and three experimental groups (ratio of icari n and simvastatin:3:1, 1:1, 1:3). Model and bone morphogenetic protein-2 control groups were given normal saline by gastric perfusion. The three experimental groups were given icari n and simvastatin solution with dosage ratios of 3:1, 1:1, 1:3 by gastric perfusion. Model group and three experimental groups were injected normal saline at fracture site, while bone morphogenetic protein-2 control group was injected bone morphogenetic protein-2 solution. Gastric perfusion was performed for 6 consecutive weeks and local injection at fracture site lasted for 2 weeks. @@@@RESULTS AND CONCLUSION:Bone morphogenetic protein-2 control group and 1:1 experimental group were the best fol owed by the 3:1 and 1:3 experimental groups, and the model group was the worst in the fol owing aspects:growth and alteration of cal us, recanalization of bone marrow cavity, bone mineral density and morphology of the fracture site. Icari n and simvastatin with different dosage ratios al can promote the radial fracture healing of rabbits. When the dosage ratio is 1:1, the combination of icari n and simvastatin can further promote fracture healing.