中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
15期
2811-2818
,共8页
组织构建%组织构建综述%脉冲电磁场%软骨细胞%软骨基质%软骨诱导%代谢%骨髓间充质干细胞%Ⅱ型胶原%蛋白多糖%转化生长因子%综述文献
組織構建%組織構建綜述%脈遲電磁場%軟骨細胞%軟骨基質%軟骨誘導%代謝%骨髓間充質榦細胞%Ⅱ型膠原%蛋白多糖%轉化生長因子%綜述文獻
조직구건%조직구건종술%맥충전자장%연골세포%연골기질%연골유도%대사%골수간충질간세포%Ⅱ형효원%단백다당%전화생장인자%종술문헌
tissue construction%tissue construction review%pulsed electromagnetic fields%chondrocytes%cartilage matrix%cartilage induction%metabolism%bone marrow mesenchymal stem cells%type Ⅱ collagen%proteoglycan%transforming growth factor%review literature
背景:目前研究已证实外周脉冲电磁场可以促进软骨代谢,但其分子水平机制仍不甚清楚.目的:探讨脉冲电磁场的物理特性及其在软骨形成方面的作用与机制.
方法:由第一作者应用计算机检索 PubMed、中国期刊全文数据库(CNKI)、维普数据库和万方数据库1997年5月至2012年8月有关脉冲电磁场对软骨代谢影响的文献.在标题、摘要、关键词中以“pulsed electromagnetic field(PEMFs),cartilage,bone marrow mesenchymal stem cel s(BMSCs)”或“脉冲电磁场,软骨代谢,软骨细胞,骨基质,骨髓间充质干细胞”为检索词进行检索.排除重复研究或内容较陈旧的文献.
结果与结论:初检得到145篇文献,排除99篇重复研究或内容较陈旧的文献,保留46篇文献进一步分析.结果显示,脉冲电磁场通过诱导骨髓间充质干细胞分化为软骨细胞,促进软骨特异性基质如Ⅱ型胶原及蛋白多糖的合成,从而发挥软骨诱导作用;脉冲电磁场通过促进转化生长因子β2与其他因子的表达,调节软骨细胞生长分化,使临床上永久性修复软骨组织缺损变为可能.
揹景:目前研究已證實外週脈遲電磁場可以促進軟骨代謝,但其分子水平機製仍不甚清楚.目的:探討脈遲電磁場的物理特性及其在軟骨形成方麵的作用與機製.
方法:由第一作者應用計算機檢索 PubMed、中國期刊全文數據庫(CNKI)、維普數據庫和萬方數據庫1997年5月至2012年8月有關脈遲電磁場對軟骨代謝影響的文獻.在標題、摘要、關鍵詞中以“pulsed electromagnetic field(PEMFs),cartilage,bone marrow mesenchymal stem cel s(BMSCs)”或“脈遲電磁場,軟骨代謝,軟骨細胞,骨基質,骨髓間充質榦細胞”為檢索詞進行檢索.排除重複研究或內容較陳舊的文獻.
結果與結論:初檢得到145篇文獻,排除99篇重複研究或內容較陳舊的文獻,保留46篇文獻進一步分析.結果顯示,脈遲電磁場通過誘導骨髓間充質榦細胞分化為軟骨細胞,促進軟骨特異性基質如Ⅱ型膠原及蛋白多糖的閤成,從而髮揮軟骨誘導作用;脈遲電磁場通過促進轉化生長因子β2與其他因子的錶達,調節軟骨細胞生長分化,使臨床上永久性脩複軟骨組織缺損變為可能.
배경:목전연구이증실외주맥충전자장가이촉진연골대사,단기분자수평궤제잉불심청초.목적:탐토맥충전자장적물리특성급기재연골형성방면적작용여궤제.
방법:유제일작자응용계산궤검색 PubMed、중국기간전문수거고(CNKI)、유보수거고화만방수거고1997년5월지2012년8월유관맥충전자장대연골대사영향적문헌.재표제、적요、관건사중이“pulsed electromagnetic field(PEMFs),cartilage,bone marrow mesenchymal stem cel s(BMSCs)”혹“맥충전자장,연골대사,연골세포,골기질,골수간충질간세포”위검색사진행검색.배제중복연구혹내용교진구적문헌.
결과여결론:초검득도145편문헌,배제99편중복연구혹내용교진구적문헌,보류46편문헌진일보분석.결과현시,맥충전자장통과유도골수간충질간세포분화위연골세포,촉진연골특이성기질여Ⅱ형효원급단백다당적합성,종이발휘연골유도작용;맥충전자장통과촉진전화생장인자β2여기타인자적표체,조절연골세포생장분화,사림상상영구성수복연골조직결손변위가능.
@@@@BACKGROUND:Peripheral pulsed electromagnetic fields have an obvious effect on cartilage metabolism;however, its molecular mechanism is stil unclear. @@@@OBJECTIVE:To investigate the physical characteristics of pulsed electromagnetic fields and its mechanism and effect on cartilage formation. @@@@METHODS:A computer-based online search of PubMed database, CNKI database, VIP database andWanfang database was performed to search related articles.“Pulsed electromagnetic fields, cartilage, cartilage cel s, matrix, bone marrow mesenchymal stem cel s”were used for word retrieval in the title, abstract, and keywords. Repetitive studies or old literatures were excluded. @@@@RESULTS AND CONCLUSION:A total of 145 articles were retrieved in the initial search, and final y 46 articles were included in result analysis. The results showed that pulsed electromagnetic fields can promote the differentiation of bone marrow mesenchymal stem cel s into chondrocytes and cartilage specific matrix such as type II col agen and proteoglycan synthesis, thus playing a cartilage inducing effect. Pulsed electromagnetic fields can also promote the expression of transforming growth factor beta 2 and other factors to regulate the chondrocyte growth and differentiation, which can realize the permanent repair of defects in clinic.
