CAJ | 학술논문

背景:转化生长因子β1可以介导软骨合成、抑制胶原和蛋白多糖分解,在诱导软骨分化和维持软骨表型上起着重要作用,实现软骨缺损的功能性修复. 目的:从生物学特性、在生物工程中的应用、基因多态性、信号通路及微小 RNA等方面综述转化生长因子β1对软骨组织代谢影响的研究进展. 方法:以“transforming growth factor-β1,Cartilage Differentiation,cartilage matrix”为英文检索词,以“转化生长因子β1,软骨分化,软骨基质”为中文检索词.经第一作者检索2007/2012CNKI数据库及SPRINGERLINK数据库有关转化生长因子β1对软骨组织代谢影响的研究进展方面的文献130篇,根据纳入排除标准保留54篇进行总结. 结果与结论:转化生长因子β1可诱导间充质细胞向软骨细胞分化,促进软骨特异性基质的合成,保护软骨基质不被各种蛋白酶水解破坏,能够增强软骨组织自身再生能力,实现使软骨的损伤逆转,在软骨修复领域展现了巨大的潜在应用价值.
배경:전화생장인자β1가이개도연골합성、억제효원화단백다당분해,재유도연골분화화유지연골표형상기착중요작용,실현연골결손적공능성수복. 목적:종생물학특성、재생물공정중적응용、기인다태성、신호통로급미소 RNA등방면종술전화생장인자β1대연골조직대사영향적연구진전. 방법:이“transforming growth factor-β1,Cartilage Differentiation,cartilage matrix”위영문검색사,이“전화생장인자β1,연골분화,연골기질”위중문검색사.경제일작자검색2007/2012CNKI수거고급SPRINGERLINK수거고유관전화생장인자β1대연골조직대사영향적연구진전방면적문헌130편,근거납입배제표준보류54편진행총결. 결과여결론:전화생장인자β1가유도간충질세포향연골세포분화,촉진연골특이성기질적합성,보호연골기질불피각충단백매수해파배,능구증강연골조직자신재생능력,실현사연골적손상역전,재연골수복영역전현료거대적잠재응용개치.
@@@@BACKGROUND:Transforming growth factor beta 1 can mediate cartilage synthesis and inhibit decomposition of col agen and protein polysaccharide, which has a most important effect on induction of cartilage differentiation in vitro and maintenance of cartilage phenotype, realizing the functional repair of cartilage defects. @@@@OBJECTIVE:Based on the biological characteristics, applications in biotechnology, gene polymorphism, signaling pathways and microRNA, to introduce research progress of transforming growth factor beta 1 influence on cartilage tissue metabolism. @@@@METHODS:The first author searched CNKI and SPRINGERLINK databases (2007/2012) to retrieve articles related to transforming growth factor beta 1 influence on cartilage tissue metabolism using the key words of“transforming growth factor beta 1, cartilage differentiation, cartilage matrix”in Chinese and English, respectively. A total of 130 articles were retrieved, and final y 54 were included. @@@@RESULTS AND CONCLUSION:Transforming growth factor beta 1 can induce chondrogenic differentiation of mesenchymal stem cel s, promote cartilage-specific matrix synthesis, protect the cartilage matrix against proteolysis, enhance self-renew ability of cartilage tissues, and realize repair of cartilage injury. In the field of cartilage repair, transforming growth factor beta 1 demonstrates a great potential value.