CAJ | 학술논문

背景:前期研究显示镁锌合金长期植入动物体内有较好的生物安全性.目的:观察将镁锌合金植入大鼠盲肠的分子生物相容性. 方法:取72只SD大鼠,随机分成假手术组、纯钛组和镁锌合金组,每组24只.假手术组仅做盲肠切开缝合,纯钛组在盲肠切口周围包埋医用纯钛,镁锌合金组在盲肠切口周围包埋镁锌合金.手术前后检测血清谷丙转氨酶、肌酐、镁离子浓度及血小板衍化生长因子浓度,以及盲肠组织中转化生长因子β1表达情况. 结果与结论:术后相同时间点3组间血清谷丙转氨酶、肌酐、镁离子浓及血清血小板衍化生长因子浓度,以及盲肠组织中转化生长因子β1表达差异无显著性意义(P>0.05).镁锌合金组术后不同时间点血小板衍化生长因子浓度明显高于术前水平(P <0.05).表明镁锌合金对大鼠肠道伤口愈合无明显影响,在肠道内有较好的分子生物相容性.
배경:전기연구현시미자합금장기식입동물체내유교호적생물안전성.목적:관찰장미자합금식입대서맹장적분자생물상용성. 방법:취72지SD대서,수궤분성가수술조、순태조화미자합금조,매조24지.가수술조부주맹장절개봉합,순태조재맹장절구주위포매의용순태,미자합금조재맹장절구주위포매미자합금.수술전후검측혈청곡병전안매、기항、미리자농도급혈소판연화생장인자농도,이급맹장조직중전화생장인자β1표체정황. 결과여결론:술후상동시간점3조간혈청곡병전안매、기항、미리자농급혈청혈소판연화생장인자농도,이급맹장조직중전화생장인자β1표체차이무현저성의의(P>0.05).미자합금조술후불동시간점혈소판연화생장인자농도명현고우술전수평(P <0.05).표명미자합금대대서장도상구유합무명현영향,재장도내유교호적분자생물상용성.
@@@@BACKGROUND:Previous studies have shown that long-term implantation of magnesium-zinc al oy into animals has a good bio-security. @@@@OBJECTIVE:To observe the molecular biocompatibility of biodegradable magnesium-zinc al oy samples implanted into the rat cecum. @@@@METHODS:Seventy-two Sprague Dawley rats were randomly divided into magnesium-zinc al oy group, medical titanium group and sham-operated group, and there were 24 rats in each group. Then magnesium-zinc al oy samples were embedded in the cecum incision in the magnesium-zinc al oy group. The medical titanium was embedded in the medical titanium group, and just suture was done in the sham-operated group. Prior to and after surgery, alanine transaminase, creatinine, magnesium ion concentrations, serum platelet-derived growth factor concentration and the expression of transforming growth factor-β1 in the cecal tissue were detected by immunohistochemistry. @@@@RESULTS AND CONCLUSION:No significant difference was determined in serum aspartate aminotransferase, creatinine, and magnesium ion concentrations, serum platelet-derived growth factor concentration and the expression of transforming growth factor-β1 among the magnesium-zinc al oy group, medical titanium group and sham-operated group at the same time point fol owing surgery (P>0.05). However, in the magnesium-zinc al oy group, the level of serum platelet-derived growth factor was significantly increased at different time after surgery (P<0.05). The magnesium-zinc al oy had no harmful effect on wound healing of the rat cecum, and posed a good biocompatibility with the rat cecum.