中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
17期
3109-3116
,共8页
汤敏生%白波%谢诗涓%龙浩%刘琦%陈艺
湯敏生%白波%謝詩涓%龍浩%劉琦%陳藝
탕민생%백파%사시연%룡호%류기%진예
骨关节植入物%骨与关节生物力学%膝内翻%膝外翻%髋臼负重顶区%关节软骨%负重面积%生物力学%应力%省级基金
骨關節植入物%骨與關節生物力學%膝內翻%膝外翻%髖臼負重頂區%關節軟骨%負重麵積%生物力學%應力%省級基金
골관절식입물%골여관절생물역학%슬내번%슬외번%관구부중정구%관절연골%부중면적%생물역학%응력%성급기금
bone and joint implants%biomechanics of bone and joint%knee varus%knee valgus%acetabular dome region%arthrodial cartilages%loading area%biomechanics%stress%provincial grants-supported paper
背景:膝内、外翻畸形改变了膝关节的形态,除影响膝关节的功能外,还可能改变相邻关节髋关节的生物力学行为,也就是髋臼与股骨头之间的力学传导.
目的:评价不同程度膝内、外翻畸形对髋臼负重顶区的生物力学影响.
方法:取成年男性鲜尸体下肢标本3个,剔除附着的肌肉组织,保留骨膜、韧带及关节囊,通过胫骨高位截骨模拟不同程度的膝内外翻畸形.标本分为中立位组、膝内翻10°组、膝内翻20°组、膝外翻10°组和膝外翻20°组.实验中骨盆的位置选择单足站立中立位.标本通过生物力学试验机加载至50 kg,采用压敏片技术测量髋臼顶负重区的负重面积、平均应力及峰值应力.
结果与结论:髋臼顶区中立位时股胫关节面负重面积为(6.33±0.12) cm2,平均应力(3.62±0.33) MPa,峰值应力为(4.58±0.20) MPa.当膝内、外翻达10°时,髋臼顶区负重面积减少,平均应力及峰值应力有明显的增加,但差异无显著性意义(P>0.05);当膝内、外翻达20°时髋臼负重面积显著减少,平均应力峰值及应力显著增加,差异有非常显著性意义(P <0.01).结果提示:随膝内、外翻畸形程度的不同,髋臼负重顶区的负重面积、峰值应力及平均应力也发生变化,当膝内、外翻达20°时,负重面积显著减少,平均应力峰值及应力显著增加,这可能是膝内外翻畸形造成髋骨关节炎的病因之一.因此临床上应重视对膝骨关节炎内、外翻畸形患者的早期干预.
揹景:膝內、外翻畸形改變瞭膝關節的形態,除影響膝關節的功能外,還可能改變相鄰關節髖關節的生物力學行為,也就是髖臼與股骨頭之間的力學傳導.
目的:評價不同程度膝內、外翻畸形對髖臼負重頂區的生物力學影響.
方法:取成年男性鮮尸體下肢標本3箇,剔除附著的肌肉組織,保留骨膜、韌帶及關節囊,通過脛骨高位截骨模擬不同程度的膝內外翻畸形.標本分為中立位組、膝內翻10°組、膝內翻20°組、膝外翻10°組和膝外翻20°組.實驗中骨盆的位置選擇單足站立中立位.標本通過生物力學試驗機加載至50 kg,採用壓敏片技術測量髖臼頂負重區的負重麵積、平均應力及峰值應力.
結果與結論:髖臼頂區中立位時股脛關節麵負重麵積為(6.33±0.12) cm2,平均應力(3.62±0.33) MPa,峰值應力為(4.58±0.20) MPa.噹膝內、外翻達10°時,髖臼頂區負重麵積減少,平均應力及峰值應力有明顯的增加,但差異無顯著性意義(P>0.05);噹膝內、外翻達20°時髖臼負重麵積顯著減少,平均應力峰值及應力顯著增加,差異有非常顯著性意義(P <0.01).結果提示:隨膝內、外翻畸形程度的不同,髖臼負重頂區的負重麵積、峰值應力及平均應力也髮生變化,噹膝內、外翻達20°時,負重麵積顯著減少,平均應力峰值及應力顯著增加,這可能是膝內外翻畸形造成髖骨關節炎的病因之一.因此臨床上應重視對膝骨關節炎內、外翻畸形患者的早期榦預.
배경:슬내、외번기형개변료슬관절적형태,제영향슬관절적공능외,환가능개변상린관절관관절적생물역학행위,야취시관구여고골두지간적역학전도.
목적:평개불동정도슬내、외번기형대관구부중정구적생물역학영향.
방법:취성년남성선시체하지표본3개,척제부착적기육조직,보류골막、인대급관절낭,통과경골고위절골모의불동정도적슬내외번기형.표본분위중립위조、슬내번10°조、슬내번20°조、슬외번10°조화슬외번20°조.실험중골분적위치선택단족참립중립위.표본통과생물역학시험궤가재지50 kg,채용압민편기술측량관구정부중구적부중면적、평균응력급봉치응력.
결과여결론:관구정구중립위시고경관절면부중면적위(6.33±0.12) cm2,평균응력(3.62±0.33) MPa,봉치응력위(4.58±0.20) MPa.당슬내、외번체10°시,관구정구부중면적감소,평균응력급봉치응력유명현적증가,단차이무현저성의의(P>0.05);당슬내、외번체20°시관구부중면적현저감소,평균응력봉치급응력현저증가,차이유비상현저성의의(P <0.01).결과제시:수슬내、외번기형정도적불동,관구부중정구적부중면적、봉치응력급평균응력야발생변화,당슬내、외번체20°시,부중면적현저감소,평균응력봉치급응력현저증가,저가능시슬내외번기형조성관골관절염적병인지일.인차림상상응중시대슬골관절염내、외번기형환자적조기간예.
@@@@BACKGROUND:Knee joint varus and valgus can change the morphology of the knee joint, influence the function of the knee joint and can change the biomechanical behavior of adjacent articular hip which is the mechanics conduction between the acetabulum and femoral head. @@@@OBJECTIVE:To investigate the effect of different varus and valgus angle on the biomechanics of acetabular dome region. @@@@METHODS:Three lower limb specimens were col ected from adult male fresh cadaver. Al muscles and connective tissues were dissected while hip and knee periosteum, joint capsules and ligaments were preserved. The high tibial osteotomy was operated to simulate different degrees of knee varus and valgus. The specimens were divided into neutral position group, knee varus 10° group, knee varus 20° group, knee valgus 20° group and knee valgus 10° group. During the experiment, the pelves were in the single-leg standing neutral position. The specimens were loaded with 50 kg by biomechanical testing machine. The loading area, mean stress, and the peak stress in the acetabular dome region were measured with pressure sensitive film system. @@@@RESULTS AND CONCLUSION:The loading area of tibiofemoral articular surface in the acetabular dome region under the neutral position was (6.33±0.12) cm2, the mean stress was (3.62±0.33) MPa and the peak stress was (4.58±0.20) MPa. When the knee joint varus and valgus for 10°, the loading area in the acetabular dome region was decreased, while the mean stress and peak stress were significantly increased, but the difference between varus and valgus 10° was no significant (P>0.05);when the knee joint varus and valgus for 20°, loading area in the acetabular dome region was significantly decreased, while the mean stress and peak stress were significantly increased, and there was significant difference between varus and valgus 20° (P<0.01). The loading area, mean stress and the peak stress distribution in hip dome region were changed with the tendency of knee varus and valgus increasing. When the knee joint varus and valgus for 20°, the loading area in the acetabular dome region was significantly decreased, while the mean stress and peak stress were significantly increased, this may be one of the factors of hip osteoarthritis caused by knee varus and valgus. Therefore, we should pay attention on the early intervention to the patients with knee osteoarthritis varus and valgus deformity in clinic.