中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
18期
22-29
,共8页
器官移植%肾移植%肾功能不全%半胱氨酸蛋白酶抑制剂C%输尿管狭窄%尿路梗阻%诊断%肌酐%尿素氮
器官移植%腎移植%腎功能不全%半胱氨痠蛋白酶抑製劑C%輸尿管狹窄%尿路梗阻%診斷%肌酐%尿素氮
기관이식%신이식%신공능불전%반광안산단백매억제제C%수뇨관협착%뇨로경조%진단%기항%뇨소담
organ transplantation%renal transplantation%renal insufficiency%cystatin C%ureteral stenosis%urinary tract obstruction%diagnosis%creatinine%urea nitrogen
背景:半胱氨酸蛋白酶抑制剂C不被肾小管分泌和重吸收,近年来被认为是一种非常理想的评价肾小球滤过率的指标.
目的:探讨肾移植后输尿管狭窄患者血清半胱氨酸蛋白酶抑制剂C水平变化及其在肾功能损伤诊断中的价值.
方法:选取2007年4月至2011年4月于深圳市第二人民医院泌尿外科及广州华侨医院泌尿外科行肾移植并于移植后发生输尿管狭窄伴肾功能不全的患者18例作为病例组,同时纳入同期年龄性别与病例组相匹配的健康体检者63名作为对照组.分别于输尿管狭窄治疗前及治疗后1个月测定患者血清半胱氨酸蛋白酶抑制剂C、肌酐、尿素氮水平并分析其相关性.
结果与结论:与对照组比较,病例组输尿管狭窄治疗前半胱氨酸蛋白酶抑制剂C、血肌酐和尿素氮水平均显著增高(P <0.01);治疗后1个月,病例组半胱氨酸蛋白酶抑制剂C、血肌酐和尿素氮水平较治疗前显著降低(P <0.01).相关分析结果显示,肾移植后输尿管狭窄患者血清半胱氨酸蛋白酶抑制剂C水平与血肌酐和尿素氮水平呈正相关.提示血清半胱氨酸蛋白酶抑制剂C可作为肾移植后肾功能恢复情况的监测指标.
揹景:半胱氨痠蛋白酶抑製劑C不被腎小管分泌和重吸收,近年來被認為是一種非常理想的評價腎小毬濾過率的指標.
目的:探討腎移植後輸尿管狹窄患者血清半胱氨痠蛋白酶抑製劑C水平變化及其在腎功能損傷診斷中的價值.
方法:選取2007年4月至2011年4月于深圳市第二人民醫院泌尿外科及廣州華僑醫院泌尿外科行腎移植併于移植後髮生輸尿管狹窄伴腎功能不全的患者18例作為病例組,同時納入同期年齡性彆與病例組相匹配的健康體檢者63名作為對照組.分彆于輸尿管狹窄治療前及治療後1箇月測定患者血清半胱氨痠蛋白酶抑製劑C、肌酐、尿素氮水平併分析其相關性.
結果與結論:與對照組比較,病例組輸尿管狹窄治療前半胱氨痠蛋白酶抑製劑C、血肌酐和尿素氮水平均顯著增高(P <0.01);治療後1箇月,病例組半胱氨痠蛋白酶抑製劑C、血肌酐和尿素氮水平較治療前顯著降低(P <0.01).相關分析結果顯示,腎移植後輸尿管狹窄患者血清半胱氨痠蛋白酶抑製劑C水平與血肌酐和尿素氮水平呈正相關.提示血清半胱氨痠蛋白酶抑製劑C可作為腎移植後腎功能恢複情況的鑑測指標.
배경:반광안산단백매억제제C불피신소관분비화중흡수,근년래피인위시일충비상이상적평개신소구려과솔적지표.
목적:탐토신이식후수뇨관협착환자혈청반광안산단백매억제제C수평변화급기재신공능손상진단중적개치.
방법:선취2007년4월지2011년4월우심수시제이인민의원비뇨외과급엄주화교의원비뇨외과행신이식병우이식후발생수뇨관협착반신공능불전적환자18례작위병례조,동시납입동기년령성별여병례조상필배적건강체검자63명작위대조조.분별우수뇨관협착치료전급치료후1개월측정환자혈청반광안산단백매억제제C、기항、뇨소담수평병분석기상관성.
결과여결론:여대조조비교,병례조수뇨관협착치료전반광안산단백매억제제C、혈기항화뇨소담수평균현저증고(P <0.01);치료후1개월,병례조반광안산단백매억제제C、혈기항화뇨소담수평교치료전현저강저(P <0.01).상관분석결과현시,신이식후수뇨관협착환자혈청반광안산단백매억제제C수평여혈기항화뇨소담수평정정상관.제시혈청반광안산단백매억제제C가작위신이식후신공능회복정황적감측지표.
@@@@BACKGROUND:As cystatin C cannot be secreted and reabsorbed by the renal tubule, it is considered as an ideal indicator to evaluate the glomerular filtration rate in recent years. @@@@OBJECTIVE:To assess the change of serum cystatin C level in ureteral stenosis patients after renal transplantation and to investigate the effect on the diagnosis of renal function impairment. @@@@METHODS:Eighteen renal transplantation patients with ureteral stenosis and renal insufficiency after renal transplantation were selected from the Department of Urology, Shenzhen Second People’s Hospital and Guangzhou Overseas Chinese Hospital as the case group, while there were 63 healthy cases in the control group whose age and gender were matched with those in the case group. The levels of serum cystatin C, serum creatinine and urea nitrogen were tested before and at 1 month after the treatment of ureteral stenosis, and the correlation was analyzed. @@@@RESULTS AND CONCLUSION:Compared with the control group, the levels of serum cystatin C, serum creatinine and urea nitrogen in the case group were increased significantly before the treatment of ureteral stenosis (P<0.01);at 1 month after treatment, the levels of serum cystatin C, serum creatinine and urea nitrogen in the case group were decreased significantly when compared with those before treatment (P<0.01). The relative analysis results showed that the serum cystatin C level of the ureteral stenosis patients was positively correlated with the levels of serum creatinine and urea nitrogen. It suggests that serum cystatin C can be regarded as one of the monitoring indicators of renal function recovery after renal transplantation.
