中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
18期
172-179
,共8页
器官移植%器官移植综述%细胞移植%帕金森病%阿尔茨海默病%肌萎缩侧索硬化%胚胎干细胞%骨髓干细胞%脐血干细胞%神经干细胞%基因
器官移植%器官移植綜述%細胞移植%帕金森病%阿爾茨海默病%肌萎縮側索硬化%胚胎榦細胞%骨髓榦細胞%臍血榦細胞%神經榦細胞%基因
기관이식%기관이식종술%세포이식%파금삼병%아이자해묵병%기위축측색경화%배태간세포%골수간세포%제혈간세포%신경간세포%기인
organ transplantation%organ transplantation review%cell transplantation%Parkinson’s disease%Alzheimer’s disease%amyotrophic lateral sclerosis%embryonic stem cells%bone marrow stem cells%umbilical cord blood stem cells%neural stem cells%gene
背景:神经变性疾病为一类缓慢起病、病程呈进行性发展、预后不良的疾病,迄今尚缺乏有效的根治方法.细胞移植为神经变性疾病的治疗提供了一个崭新的思路.
目的:研究细胞移植治疗神经变性疾病的移植细胞、修饰基因及方法,并探讨细胞移植后是否发生“转分化”.
方法:收集细胞移植治疗神经变性疾病的相关文献,分析近年相关研究中细胞移植治疗神经变性疾病的移植细胞、修饰基因,以及细胞移植治疗帕金森病、阿尔茨海默病和肌萎缩侧索硬化的方法.
结果与结论:目前治疗神经变性疾病研究较多的主要为骨髓干细胞、胚胎干细胞、脐血干细胞、神经干细胞、异体细胞等.细胞移植治疗神经变性疾病时的修饰基因主要有酪氨酸羟化酶、孤儿核受体、神经营养因子、Von Hippel-Lindau基因、白细胞介素1及褪黑素等.细胞移植治疗帕金森病多是移植到大鼠纹状体,细胞移植治疗阿尔茨海默病和肌萎缩侧索硬化的移植部位分别多为海马和蛛网膜下腔.细胞移植应用于治疗神经变性疾病正日趋成熟,但移植后是否真的发生了细胞的“转分化”,尚无明确的结论.
揹景:神經變性疾病為一類緩慢起病、病程呈進行性髮展、預後不良的疾病,迄今尚缺乏有效的根治方法.細胞移植為神經變性疾病的治療提供瞭一箇嶄新的思路.
目的:研究細胞移植治療神經變性疾病的移植細胞、脩飾基因及方法,併探討細胞移植後是否髮生“轉分化”.
方法:收集細胞移植治療神經變性疾病的相關文獻,分析近年相關研究中細胞移植治療神經變性疾病的移植細胞、脩飾基因,以及細胞移植治療帕金森病、阿爾茨海默病和肌萎縮側索硬化的方法.
結果與結論:目前治療神經變性疾病研究較多的主要為骨髓榦細胞、胚胎榦細胞、臍血榦細胞、神經榦細胞、異體細胞等.細胞移植治療神經變性疾病時的脩飾基因主要有酪氨痠羥化酶、孤兒覈受體、神經營養因子、Von Hippel-Lindau基因、白細胞介素1及褪黑素等.細胞移植治療帕金森病多是移植到大鼠紋狀體,細胞移植治療阿爾茨海默病和肌萎縮側索硬化的移植部位分彆多為海馬和蛛網膜下腔.細胞移植應用于治療神經變性疾病正日趨成熟,但移植後是否真的髮生瞭細胞的“轉分化”,尚無明確的結論.
배경:신경변성질병위일류완만기병、병정정진행성발전、예후불량적질병,흘금상결핍유효적근치방법.세포이식위신경변성질병적치료제공료일개참신적사로.
목적:연구세포이식치료신경변성질병적이식세포、수식기인급방법,병탐토세포이식후시부발생“전분화”.
방법:수집세포이식치료신경변성질병적상관문헌,분석근년상관연구중세포이식치료신경변성질병적이식세포、수식기인,이급세포이식치료파금삼병、아이자해묵병화기위축측색경화적방법.
결과여결론:목전치료신경변성질병연구교다적주요위골수간세포、배태간세포、제혈간세포、신경간세포、이체세포등.세포이식치료신경변성질병시적수식기인주요유락안산간화매、고인핵수체、신경영양인자、Von Hippel-Lindau기인、백세포개소1급퇴흑소등.세포이식치료파금삼병다시이식도대서문상체,세포이식치료아이자해묵병화기위축측색경화적이식부위분별다위해마화주망막하강.세포이식응용우치료신경변성질병정일추성숙,단이식후시부진적발생료세포적“전분화”,상무명학적결론.
@@@@BACKGROUND:Neurodegenerative disease is a kind of disease with slow onset, progressive duration and poor prognosis, so far, there is no effective treatment method. Cel transplantation provides a new idea for the treatment of neurodegenerative disease. @@@@OBJECTIVE:To observe the trasplated cel s, modifiers and methods used in cel transplantation for the treatment of neurodegenerative disease, and to explore whether“transdifferentiation”appeared after cel transplantation. @@@@METHODS:Articles related to cel transplantation for the treatment of neurodegenerative disease were col ected, and the transplanted cel s and modifiers used in cel transplantation for the treatment of neurodegenerative disease were analyzed, as wel as the method of cel transplantation for the treatment of Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis. @@@@RESULTS AND CONCLUSION:At present, the research on the treatment of neurodegenerative disease are mainly focus on bone marrow stem cel s, embryonic stem cel s, umbilical cord blood stem cel s, neural stem cel s and al ogeneic cel s. The modifiers used in cel transplantation for the treatment of neurodegenerative disease includs tyrosine hydroxylase, orphan nuclear receptor, neurotrophic factor, Von Hippel-Lindau gene, interleukin-1 and melatonin. Cel transplantation can treat Parkinson’s disease by transplanting the cel s into rat striatum, and cel transplantation can treat Alzheimer’s disease and amyotrophic lateral sclerosis by transplanting the cel s into the hippocampus region and subarachnoid space. Cel transplantation for the treatment of neurodegenerative disease is becoming more mature, but there is no clear conclusion on whether“transdifferentiation”appears after transplantation.
