CAJ | 학술논문

目的:研究钙离子通道抑制剂miconazole对破骨细胞对羟基磷灰石涂层的吸收的影响.方法:在羟基磷灰石涂层表面诱导破骨细胞,破骨细胞形成后,分别加入不同浓度的miconazole细胞培养基,培养48h后,扫描电镜观察羟基磷灰石表层的吸收陷窝.结果:miconazole可抑制破骨细胞的羟基磷灰石涂层的吸收陷窝面积,且吸收陷窝面积随着miconazole浓度的增加而增加.结论:miconazole可抑制破骨细胞对羟基磷灰石涂层的吸收.
목적:연구개리자통도억제제miconazole대파골세포대간기린회석도층적흡수적영향.방법:재간기린회석도층표면유도파골세포,파골세포형성후,분별가입불동농도적miconazole세포배양기,배양48h후,소묘전경관찰간기린회석표층적흡수함와.결과:miconazole가억제파골세포적간기린회석도층적흡수함와면적,차흡수함와면적수착miconazole농도적증가이증가.결론:miconazole가억제파골세포대간기린회석도층적흡수.
@@@@Objective:To research the effect of miconazole on the osteoclastic resorption ability on hydroxyap-atite (HA) coating surface. Methods: Osteoclasts were generated on HA coating surface. After osteo-clasts were generated, different concentrations of miconazole was added and cocultured for 48h. The re-sorption pits on the surface was measured by SEM and the resorption area were measured. Results: Mi-conazole inhibited resorption area on HA coating surface in a dose dependent manner. Conclusion: Mi-conazole inhibited osteoclastic resorpiton on HA coating surface.