CAJ | 학술논문

目的探讨氯磷定在急性毒死蜱中毒中的应用方法.方法将20例急性毒死蜱中毒患者分A组和B组.A组给予彻底清除毒物,尽早应用阿托品等常规治疗,氯磷定采用传统的反复肌肉注射法;B组氯磷定采用微量泵持续泵入法,其余治疗同A组.比较各组患者的临床疗效和治疗7d内血清胆碱脂酶的活性变化.结果 A组的阿托品总用量、阿托品中毒发生率、反跳率和平均住院天数明显高于B组(P <0.01),而B组的氯磷定总用量显著多于A组(P <0.01).治疗7d内,B组血清胆碱酯酶活性恢复显著快于A组(P <0.01).结论急性毒死蜱中毒的救治中,增加氯磷定日总量,采用静脉持续泵入,延长用药时间,经观察疗效明显,用药安全.
목적탐토록린정재급성독사비중독중적응용방법.방법장20례급성독사비중독환자분A조화B조.A조급여철저청제독물,진조응용아탁품등상규치료,록린정채용전통적반복기육주사법;B조록린정채용미량빙지속빙입법,기여치료동A조.비교각조환자적림상료효화치료7d내혈청담감지매적활성변화.결과 A조적아탁품총용량、아탁품중독발생솔、반도솔화평균주원천수명현고우B조(P <0.01),이B조적록린정총용량현저다우A조(P <0.01).치료7d내,B조혈청담감지매활성회복현저쾌우A조(P <0.01).결론급성독사비중독적구치중,증가록린정일총량,채용정맥지속빙입,연장용약시간,경관찰료효명현,용약안전.
@@@@Objective To evaluate the efficacy of pralidoxime chloride by continuous intravenous infusion in treatment of acute chlorpyrifos poisoning. Methods 20 patients with acute chlorpyrifos poisoning were enrolled and divided into A group and B group. In A group, pralidoxime chloride was given by intramuscular injection at regular intervals;in B group, pralidoxime chloride was used continually by syringe pump. All patients accepted traditional treatment including gastric lavage, catharsis, emetic and atropine. The clinical efficacy and cholinesterase activity were compared between groups. Results In A group, the cumulative dosage of atropine and the frequency of atropine poisoning and intoxicated rebound and average hospitalization days were significantly higher than those in B group(P<0.01). The cumulative dosage of pralidoxime chloride in B group was markedly higher than that in A group(P<0.01). The cholinesterase activities determined after 7 days treatment in B group were significantly higher than A group's at the same time(P<0.01). Conclusion There was remarkably therapeutic efficacy by using pralidoxime chloride continually by syringe pump and increasing the total dosage of pralidoxime chloride in 24 hours in treatment of acute chlorpyrifos poisoning.