CAJ | 학술논문

目的探讨辛伐他汀辅助治疗糖尿病并慢性心力衰竭的临床效果.方法选取我院自2010年2月至2011年2月所收治的糖尿病合并慢性心力衰竭患者94例为研究对象,按照随机抽取的方式将其划分为治疗组与对照组,每组患者各计47例.治疗组患者在给予常规DM-2治疗的基础之上,选取辛伐他丁药物进行辅助慢性心力衰竭病症的治疗.对照组患者给予常规DM-2治疗.针对两组患者在3个月治疗后所表现出的治疗有效性(治疗有效性的评定指标选取血清总胆固醇,血清三酰甘油,左室射血分数以及C反应蛋白),治疗过程中的并发症发生率,治疗后期随访1年时间内所表现出的病死率指标进行详细分析与比较.结果治疗期间两组均未见明显药物副反应,两组TC,TG,LVEF和C-RP均有显著性改善(均P<0.01).治疗后观察组TC,TG和C-RP均显著低于对照组(均P<0.01),LVEF显著高于对照组(P<0.01).随访1年时间内,观察组患者病死率明显低于对照组患者病死率,两组数据组间比较差异显著(P<0.05),差异有统计学意义.结论辛伐他汀对于2型糖尿病和慢性心力衰竭均有较好的辅助治疗效果,可以在更好控制2型糖尿病血流动力学紊乱的基础上,更加有效的改善慢性心力衰竭病情,值得临床考虑.
목적탐토신벌타정보조치료당뇨병병만성심력쇠갈적림상효과.방법선취아원자2010년2월지2011년2월소수치적당뇨병합병만성심력쇠갈환자94례위연구대상,안조수궤추취적방식장기화분위치료조여대조조,매조환자각계47례.치료조환자재급여상규DM-2치료적기출지상,선취신벌타정약물진행보조만성심력쇠갈병증적치료.대조조환자급여상규DM-2치료.침대량조환자재3개월치료후소표현출적치료유효성(치료유효성적평정지표선취혈청총담고순,혈청삼선감유,좌실사혈분수이급C반응단백),치료과정중적병발증발생솔,치료후기수방1년시간내소표현출적병사솔지표진행상세분석여비교.결과치료기간량조균미견명현약물부반응,량조TC,TG,LVEF화C-RP균유현저성개선(균P<0.01).치료후관찰조TC,TG화C-RP균현저저우대조조(균P<0.01),LVEF현저고우대조조(P<0.01).수방1년시간내,관찰조환자병사솔명현저우대조조환자병사솔,량조수거조간비교차이현저(P<0.05),차이유통계학의의.결론신벌타정대우2형당뇨병화만성심력쇠갈균유교호적보조치료효과,가이재경호공제2형당뇨병혈류동역학문란적기출상,경가유효적개선만성심력쇠갈병정,치득림상고필.
Objective To explore the clinical effect of adjuvant therapy of simvastatin used for diabetes mellitus combined with chronic heart failure. Methods 94 cases of diabetes mellitus of type-2 combined with chronic heart failure were randomly divided into observational group and control group .The same therapy of diabetes mellitus of type-2 were given two groups, and routine therapy of chronic heart failure were given two groups, experimental group were added with simvastatin. Results There was no obvious side-reactions during therapy time, TC,TG,LVEF and C-RP of two groups changed significantly better (all P<0.01). After therapy, TC,TG and C-RP significantly lower than control group(all P<0.01), and LVEF were significantly higher than control group (P<0.01). Followed for 1 year period, the mortality rate of the observation group was significantly lower than the control group mortality difference between the two sets of data groups significantly (P<0.05), the difference was statistically significant.Conclusion Simvastatin own good adjuvant effect for both diabetes mellitus of type-2 and chronic heart failure, it can be the base of better controlling of hemodynamics of diabetes mellitus of type-2, to improve the disease of chronic heart failure, so it deserved in clinical work.