CAJ | 학술논문

目的探讨不同浓度的镁离子透析液对维持性血液透析(MHD)患者的甲状旁腺激素影响.方法选60例在潍坊市人民医院行规律血液透析的患者,随机分成A和B两组,A组以镁离子浓度为0.5mmol/L的透析液完成血液透析4周,B组以镁离子浓度为0.75mmol/L的透析液也同时完成血液透析4周.分别于研究开始前及每周的中间透析日于透析上机前抽血化验相关指标.比较不同浓度的镁离子透析液对白蛋白、钙、磷、镁、甲状旁腺激素、以及肌酐、尿素氮的影响.结果①B组患者的血清镁(sMg)的水平明显高于A组患者血清镁的水平(P<0.01).②B组患者PTH水平低于A组.PTH水平与血清镁水平呈负相关(r=-0.518,P<0.05).结论 sMg的升高在一定程度上可使PTH浓度降低.
목적탐토불동농도적미리자투석액대유지성혈액투석(MHD)환자적갑상방선격소영향.방법선60례재유방시인민의원행규률혈액투석적환자,수궤분성A화B량조,A조이미리자농도위0.5mmol/L적투석액완성혈액투석4주,B조이미리자농도위0.75mmol/L적투석액야동시완성혈액투석4주.분별우연구개시전급매주적중간투석일우투석상궤전추혈화험상관지표.비교불동농도적미리자투석액대백단백、개、린、미、갑상방선격소、이급기항、뇨소담적영향.결과①B조환자적혈청미(sMg)적수평명현고우A조환자혈청미적수평(P<0.01).②B조환자PTH수평저우A조.PTH수평여혈청미수평정부상관(r=-0.518,P<0.05).결론 sMg적승고재일정정도상가사PTH농도강저.
Objective The aim was to investigate the relationship between different concentration of magnesium in dialysiate fluid and serum parathyroid hormone in MHD patients. Methods The study was carried out in 60 MHD patients of Weifang people's hospital. Patients were randomly divided into two groups:group A (MdMg group), in which patients were given dialysate fluid for four weeks which the concentration of magnesium is 0.5mmol/L. and group B (HdMg group), in which patients received hemodialysate fluid of 0.75 mmol/L dMg(dialysate magesium) consecutively. The study collected the related index before the experiment firstly and on every midweek of dialysate .Results Compared with group A, the sMg of group B was significantly higher(P<0.01), the PTH were lower. The level of sMg was negative correlation with PTH(r=-0.518, P<0.05). Conclusion The serum magnesium is relevant with PTH in MHD patients. To some extent, Hypermagnesemia inhibits PTH secretion.