中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
8期
46
,共1页
潘文嘉%林晓%蔡海珠%林坚涛*
潘文嘉%林曉%蔡海珠%林堅濤*
반문가%림효%채해주%림견도*
复方氯霉素滴耳液%氯霉素%地塞米松磷酸钠%高效液相色谱法
複方氯黴素滴耳液%氯黴素%地塞米鬆燐痠鈉%高效液相色譜法
복방록매소적이액%록매소%지새미송린산납%고효액상색보법
Compound chloramphenicol ear drops%Chloramphenicol%Dexamethasone sodium phosphate%Performance liquid chromatography
目的建立复方氯霉素滴耳液的质量标准.方法采用高效液相色谱法对复方氯霉素滴耳液中的氯霉素和地塞米松磷酸钠进行定性鉴别及含量测定.结果在高效液相色谱法中,氯霉素在0.02652~0.2122mg/mL范围内线性关系良好(r2=0.9999),平均回收率为99.2%,RSD=0.19%;地塞米松磷酸钠在0.01068~0.08262mg/mL范围内线性关系良好(r2=0.9999),平均回收率为101.5%,RSD=0.47%.结论所建立的方法能可靠准确地进行定性定量测定,可用于复方氯霉素滴耳液的质量控制.
目的建立複方氯黴素滴耳液的質量標準.方法採用高效液相色譜法對複方氯黴素滴耳液中的氯黴素和地塞米鬆燐痠鈉進行定性鑒彆及含量測定.結果在高效液相色譜法中,氯黴素在0.02652~0.2122mg/mL範圍內線性關繫良好(r2=0.9999),平均迴收率為99.2%,RSD=0.19%;地塞米鬆燐痠鈉在0.01068~0.08262mg/mL範圍內線性關繫良好(r2=0.9999),平均迴收率為101.5%,RSD=0.47%.結論所建立的方法能可靠準確地進行定性定量測定,可用于複方氯黴素滴耳液的質量控製.
목적건립복방록매소적이액적질량표준.방법채용고효액상색보법대복방록매소적이액중적록매소화지새미송린산납진행정성감별급함량측정.결과재고효액상색보법중,록매소재0.02652~0.2122mg/mL범위내선성관계량호(r2=0.9999),평균회수솔위99.2%,RSD=0.19%;지새미송린산납재0.01068~0.08262mg/mL범위내선성관계량호(r2=0.9999),평균회수솔위101.5%,RSD=0.47%.결론소건립적방법능가고준학지진행정성정량측정,가용우복방록매소적이액적질량공제.
Objective To establish a method for the quality control of compound chloramphenicol auristillae. Methods The discrimination and determination of compound chloramphenicol auristillae were performed by the high performance liquid chromatography (HPLC). Results The linear range for chloramphenicol was 0.02652~0.2122mg/mL ,the average recovery rate was 99.2%,RSD was 0.19%;The linear range for Dexamethasone Sodium Phosphate was 0.01068~0.08262mg/mL ,the average recovery rate was 101.5%,RSD was 0.47%. Conclusion The method is reliable and accurate, and can be applied to the quality control of compound chloramphenicol auristillae.
