CAJ | 학술논문

目的探讨2型糖尿病视网膜病变与血清脂蛋白(a)的关系及其临床意义.方法检测了40例2型糖尿病患者的视网膜情况.按DR分期标准将该40例患者分为糖尿病正常眼底、糖尿病视网膜病变组(糖尿病DR组)各20例,并设正常对照组20例.测定了三组人群的血清Lp(a)水平,同时测定了三组人群的TC、LDL-c、HDL-c和TG水平,分析了其与血清Lp(a)的相关性.结果糖尿病正常眼底组apoB、TG、TC、LDL、Lp(a)水平较健康对照组升高,HDL-C降低,有显著性差异(P<0.05);糖尿病DR组apoB、TC、LDL、Lp(a)较NIDDM组正常眼底组明显升高,HDL-C、ApoA1降低,有显著性差异(P<0.05),TG水平无显著性差异.扣除其他因素影响,Lp(a)与TC(r=0.773,P<0.05)、LDL(r=0.784,P<0.05)均呈正相关,Lp(a)与ApoAI、ApoB、TG、LDL-C无相关性.结论 Lp(a)水平在糖尿病DR组明显升高糖尿病正常眼底组,提示Lp(a)水平可能是2型糖尿病视网膜病变发生和加重的重要因素.
목적탐토2형당뇨병시망막병변여혈청지단백(a)적관계급기림상의의.방법검측료40례2형당뇨병환자적시망막정황.안DR분기표준장해40례환자분위당뇨병정상안저、당뇨병시망막병변조(당뇨병DR조)각20례,병설정상대조조20례.측정료삼조인군적혈청Lp(a)수평,동시측정료삼조인군적TC、LDL-c、HDL-c화TG수평,분석료기여혈청Lp(a)적상관성.결과당뇨병정상안저조apoB、TG、TC、LDL、Lp(a)수평교건강대조조승고,HDL-C강저,유현저성차이(P<0.05);당뇨병DR조apoB、TC、LDL、Lp(a)교NIDDM조정상안저조명현승고,HDL-C、ApoA1강저,유현저성차이(P<0.05),TG수평무현저성차이.구제기타인소영향,Lp(a)여TC(r=0.773,P<0.05)、LDL(r=0.784,P<0.05)균정정상관,Lp(a)여ApoAI、ApoB、TG、LDL-C무상관성.결론 Lp(a)수평재당뇨병DR조명현승고당뇨병정상안저조,제시Lp(a)수평가능시2형당뇨병시망막병변발생화가중적중요인소.
Objective To investigate the changes of serum Lp(a) levels of patients with type-2 diabetes mellitus complicated by diabetic retinopathy and its clinical significance. Method We tested serum Lp(a) levels of normal control subjects, Type-2 diabetics and those accompanied with diabetic retinopathy complications. Meanwhile, the levels of TG, TC, LDL-C, and HDL-C for the three groups were measured and the relationship of Lp(a) to the disease were analyged. Results It was found that the Lp(a), TC and LDL-C in one group patients (diabetes mellitus complicated by diabetic retinopathy) were significantly higher than that in the other two groups (P<0.05);and there is no similar changes of serum TG (P>0.05). Conclusion The serum Lp(a) levels are increased in Type-2 diabetes and more obviously higher in diabetes with diabetic retinopathy, showing certain clinical and practical value.