CAJ | 학술논문

目的探讨难治复发性淋巴瘤患者细胞免疫、红细胞免疫及肿瘤标志物的变化规律.方法2009年7月至2012年6月治疗的25例难治复发性淋巴瘤患者为观察组,同期的25例治疗有效患者为对照组,将两组患者的细胞免疫、红细胞免疫及肿瘤标志物水平进行检测及比较.结果观察组的CD3+、CD4+、CD4/CD8及NK均低于对照组,CD8+高于对照组,RBC-C3bR及RFER均低于对照组,RBC-ICR及RFIR高于对照组,肿瘤标志物均高于对照组,且Ⅲ~Ⅳ期患者变化幅度均大于Ⅰ~Ⅱ期患者,差异有统计学意义(P均<0.05).结论难治复发性淋巴瘤患者的免疫状态较低,且肿瘤标志物水平较高.
목적탐토난치복발성림파류환자세포면역、홍세포면역급종류표지물적변화규률.방법2009년7월지2012년6월치료적25례난치복발성림파류환자위관찰조,동기적25례치료유효환자위대조조,장량조환자적세포면역、홍세포면역급종류표지물수평진행검측급비교.결과관찰조적CD3+、CD4+、CD4/CD8급NK균저우대조조,CD8+고우대조조,RBC-C3bR급RFER균저우대조조,RBC-ICR급RFIR고우대조조,종류표지물균고우대조조,차Ⅲ~Ⅳ기환자변화폭도균대우Ⅰ~Ⅱ기환자,차이유통계학의의(P균<0.05).결론난치복발성림파류환자적면역상태교저,차종류표지물수평교고.
Objective To study the variation of cellular immunity,red cell immune and tumor markers of patients with relapsed and refractory lymphoma.Methods 25 patients with relapsed and refractory lymphoma in ourhospital from July 2009 to June 2012 were selected as observation group,and 25 patients who were effectively treated at the same time were selected control group,then the cellular immunity,red cell immune and tumor markers of two groups were detected and compared. Results The CD3+,CD4+,CD4/CD8 and NK of observation group were lower than those of control group,CD8+ were higher than those of control group,RBC-C3bR and RFER were lower than those of control group,RBC-ICR and RFIR were higher than those of control group,serum tumor markers were all higher than those of control group,and the those items change range of stageⅢandⅣwere bigger than those of stageⅠandⅡ,all P<0.05,there were all significant differences. Conclusion The immune state of patients with relapsed and refractory lymphoma is lower,and their tumor markers are higher.