分子诊断与治疗杂志
分子診斷與治療雜誌
분자진단여치료잡지
JOURNAL OF MOLECULAR DIAGNOSIS AND THERAPY
2013年
3期
173-176
,共4页
恐惧%心理应激%内分泌免疫
恐懼%心理應激%內分泌免疫
공구%심리응격%내분비면역
Fear stress%Psychological stress%Endocrine-immune
目的 探索“恐惧”情绪应激对大鼠内分泌及免疫系统的影响. 方法 根据Takashi方法建立恐惧应激模型,通过放射免疫方法检测ACTH、CORT、IL-2和IL-8,并与正常组、孤独饲养组进行对照.结果 各组大鼠ACTH、CORT均有显著差异(F 值分别10.466、13.804;均为P<0.01).恐惧模型组ACTH、CORT水平高于正常对照组及孤独饲养组.各组大鼠IL-8比较,存在显著差异(F=3.489,P=0.049),恐惧模型组血清IL-8水平高于正常对照组,各组大鼠IL-2未见显著差异(F=1.355, P=0.280). 结论 恐惧可通过激活HPA轴,升高ACTH、CORT水平这一途径调控应激反应.恐惧应激可提高IL-8水平,对机体免疫功能有抑制作用.
目的 探索“恐懼”情緒應激對大鼠內分泌及免疫繫統的影響. 方法 根據Takashi方法建立恐懼應激模型,通過放射免疫方法檢測ACTH、CORT、IL-2和IL-8,併與正常組、孤獨飼養組進行對照.結果 各組大鼠ACTH、CORT均有顯著差異(F 值分彆10.466、13.804;均為P<0.01).恐懼模型組ACTH、CORT水平高于正常對照組及孤獨飼養組.各組大鼠IL-8比較,存在顯著差異(F=3.489,P=0.049),恐懼模型組血清IL-8水平高于正常對照組,各組大鼠IL-2未見顯著差異(F=1.355, P=0.280). 結論 恐懼可通過激活HPA軸,升高ACTH、CORT水平這一途徑調控應激反應.恐懼應激可提高IL-8水平,對機體免疫功能有抑製作用.
목적 탐색“공구”정서응격대대서내분비급면역계통적영향. 방법 근거Takashi방법건립공구응격모형,통과방사면역방법검측ACTH、CORT、IL-2화IL-8,병여정상조、고독사양조진행대조.결과 각조대서ACTH、CORT균유현저차이(F 치분별10.466、13.804;균위P<0.01).공구모형조ACTH、CORT수평고우정상대조조급고독사양조.각조대서IL-8비교,존재현저차이(F=3.489,P=0.049),공구모형조혈청IL-8수평고우정상대조조,각조대서IL-2미견현저차이(F=1.355, P=0.280). 결론 공구가통과격활HPA축,승고ACTH、CORT수평저일도경조공응격반응.공구응격가제고IL-8수평,대궤체면역공능유억제작용.
@@@@ Objective To investigate the effects of fear stress on the endocrine and immune systems of rats with fear stress. Methods The fear stress model was established according to Takashis' method. Then, the average contents of ACTH, CORT, IL-2, IL-8 detected by radio immunoassay method were compared in fear group, breed lonely group and normal group. Results There was significantly difference for the level of ACTH and CORT among three groups (F=10.466, 13.804;P<0.01). Fear stress could increase the level of ACTH and CORT, compared with other two groups (P<0.05).There was significantly difference for the level of IL-8 among three groups (F=3.489;P=0.049) Fear stress could increase the level of IL-8, compared with normal control group (P<0.05). For the level of IL-2, there was no significantly difference among three groups (F=1.355,P=0.280). Conclusion Fear could regulate and control the stress response by activating HPA axis and increasing the level of ACTH and CORT. Fear stress could suppress the immune system by increasing the level of IL-8.
