CAJ | 학술논문

非编码RNA参与了多种疾病尤其是肿瘤发生发展的调控过程,是近期研究热点之一.随着高通量筛选方法的完善,越来越多的lncRNA分子被发现,并有望成为新型肿瘤诊断标志物和肿瘤治疗的靶点.近期研究提示lncRNA在肿瘤诊断和治疗方面具有良好的临床应用前景.本文介绍了lncRNA近期研究进展,相关lncRNA数据库的使用,并着重介绍了lncRNA与肿瘤诊断和预后关系研究情况.
비편마RNA삼여료다충질병우기시종류발생발전적조공과정,시근기연구열점지일.수착고통량사선방법적완선,월래월다적lncRNA분자피발현,병유망성위신형종류진단표지물화종류치료적파점.근기연구제시lncRNA재종류진단화치료방면구유량호적림상응용전경.본문개소료lncRNA근기연구진전,상관lncRNA수거고적사용,병착중개소료lncRNA여종류진단화예후관계연구정황.
@@@@ Non-coding RNAs (ncRNAs) are involved in a variety of diseases, and especially in the regulation of the tumor occurrence and development. Nowadays, more reserchers focus on these functional RNAs instead of protein-coding genes. With the improvement of high-throughput screening method, more and more lncRNAs are found, and are expected to become new tumor diagnostic markers and targets of cancer therapy. Also, recent studies have indicated that the lncRNA is a good candidate for clinical application in tumor diagnosis and treatment. Now, the review describes recent research progress about lncRNAs, including the usage of lncRNA databases and the relationship between lncRNAs and tumor diagnosis and prognosis.