CAJ | 학술논문

近年来,能够精确控制尺寸、形态、组成的纳米微粒制备方法的研究成为科学研究的难点与热点.本文简述了一项新型的纳米微粒制备技术:非浸润模板微印制技术(PRINT,particle replication in non-wetting templates),该技术是将微细加工技术应用到材料合成领域,以不亲水不亲油的含氟材料为模板,预先根据所需微结构的尺寸、形态设计制作模板,利用模板的空间局限作用,压印制备特定尺寸、形态、取向、排布的单分散载药微粒.重点阐述了PRINT技术微粒制备的方法以及在抗癌载药微粒的制备与应用,最后总结指出由PRINT技术制备的多种不同高宽比的形态抗癌载药微粒在病体细胞中具有不同的释药效果,该项技术在纳米微粒制备领域的突破有望推动纳米医药与生物诊断研究领域的巨大发展.
근년래,능구정학공제척촌、형태、조성적납미미립제비방법적연구성위과학연구적난점여열점.본문간술료일항신형적납미미립제비기술:비침윤모판미인제기술(PRINT,particle replication in non-wetting templates),해기술시장미세가공기술응용도재료합성영역,이불친수불친유적함불재료위모판,예선근거소수미결구적척촌、형태설계제작모판,이용모판적공간국한작용,압인제비특정척촌、형태、취향、배포적단분산재약미립.중점천술료PRINT기술미립제비적방법이급재항암재약미립적제비여응용,최후총결지출유PRINT기술제비적다충불동고관비적형태항암재약미립재병체세포중구유불동적석약효과,해항기술재납미미립제비영역적돌파유망추동납미의약여생물진단연구영역적거대발전.
In recent years,a method to produce shape-specific nanoparticles which can load any cargo has become a hot and difficult area of research. This review starts with a brief introduction of the advanced nanoparticles,which can load any cargo. A novel method called PRINT (particle replication in non-wetting templates) can be used to design and prepare the templates through the low surface energy perfluoropolyether network. By the confined space of template,shape-controlled particles are fabricated. The method of nanofabrication and application in loading anti-cancer drug is summarized. The anti-cancer drug particles with different haspect ratios contributes to different drug release rates. This breakthrough in nanotechnology will have tremendous potential for applications in nanomedicine and diagnostics.