CAJ | 학술논문

目的建立测定格拉司琼中甲醇、乙醇、二氯甲烷、异丙醇、乙酸乙酯、四氢呋喃残留有机溶剂含量的顶空气相色谱法.方法采用顶空气相色谱法,FID检测器,以二甲基亚砜为溶媒,顶空预热温度为95℃,预热时间为25min,进样口温度为180℃,检测器温度为250℃,以氮气为载气,使用DB-624交联毛细管柱(30m×0.53mm.i.d,3μm),采用程序升温,实现了各组分的基线分离.结果甲醇、乙醇、二氯甲烷、异丙醇、乙酸乙酯、四氢呋喃在各自对应的浓度范围内,线性关系良好;甲醇、乙醇、二氯甲烷、异丙醇、乙酸乙酯、四氢呋喃的最小检测限分别为0.01μg/mL、0.19μg/mL、0.02μg/mL、0.18μg/mL、0.02μg/mL、0.003μg/mL;加样回收率均在95%以上,精密度良好.结论经方法学验证,该方法灵敏、准确、可靠,可适用于格拉司琼中甲醇、乙醇、二氯甲烷、异丙醇、乙酸乙酯、四氢呋喃残留有机溶剂的测定.
목적건립측정격랍사경중갑순、을순、이록갑완、이병순、을산을지、사경부남잔류유궤용제함량적정공기상색보법.방법채용정공기상색보법,FID검측기,이이갑기아풍위용매,정공예열온도위95℃,예열시간위25min,진양구온도위180℃,검측기온도위250℃,이담기위재기,사용DB-624교련모세관주(30m×0.53mm.i.d,3μm),채용정서승온,실현료각조분적기선분리.결과갑순、을순、이록갑완、이병순、을산을지、사경부남재각자대응적농도범위내,선성관계량호;갑순、을순、이록갑완、이병순、을산을지、사경부남적최소검측한분별위0.01μg/mL、0.19μg/mL、0.02μg/mL、0.18μg/mL、0.02μg/mL、0.003μg/mL;가양회수솔균재95%이상,정밀도량호.결론경방법학험증,해방법령민、준학、가고,가괄용우격랍사경중갑순、을순、이록갑완、이병순、을산을지、사경부남잔류유궤용제적측정.
Objective This paper reports a Head-space GC method for determination of methanol,enthanol,2-propanol,dichlor omethane,ethylacetate,tetrahy drofuran in granisetron.Method The analytical column was DB-624(30m×0.53mm.i.d,3μm). The injector temperature was 180℃ and the detector temperature was 250℃.The column temperature was programmed raised.The carrier gas was nitrogen and the solvent was diethyl suffixed.Results The stand curve were linear for each solvents in the range of each consistency.The average recoveries were all more than 95%.Conclusion This method is simple,rapid and precise,it is suitable for measurement of residual solvents in Granisetron.