中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
21期
3907-3913
,共7页
刘梅天%聂红兵%张金婷%周海静
劉梅天%聶紅兵%張金婷%週海靜
류매천%섭홍병%장금정%주해정
生物材料%组织工程口腔材料%抗菌活性%甲基丙烯酰氧十二烷基溴吡%复合树脂%变形链球菌%单体%粘接剂%省级基金
生物材料%組織工程口腔材料%抗菌活性%甲基丙烯酰氧十二烷基溴吡%複閤樹脂%變形鏈毬菌%單體%粘接劑%省級基金
생물재료%조직공정구강재료%항균활성%갑기병희선양십이완기추필%복합수지%변형련구균%단체%점접제%성급기금
biomaterials%tissue-engineered oral materials%antibacterial activity%12-methacryloyloxydodecylpyridinium bromide%composite resin%Streptococcus mutans%monomer%adhesive%provincial grants-supported paper
背景:研究证实粘接修复技术治疗龋病过程中,龋洞预备后残留的细菌可在牙体组织与修复体之间继续生存较长时间,诱发继发龋或牙髓的慢性炎症.目的:评价经甲基丙烯酰氧十二烷基溴吡单体改性树脂基粘接剂对变形链球菌的抗菌性能.方法:制备含质量分数0(阴性对照),1%,2%,3%,4%甲基丙烯酰氧十二烷基溴吡抗菌单体的实验性GLUMA Comfort Bond粘接剂样本,以Clearfil Protect bond粘接剂为阳性对照;分别涂布在复合树脂试件表面并固化,在变形链球菌液体培养基中进行培养,培养18 h后检测菌液的A值、pH值.结果与结论:GLUMA Comfort Bond 粘接剂对变形链球菌生长及产酸能力无明显抑制作用,Clearfil Protect bond粘接剂对变形链球菌生长及产酸能力有明显抑制作用.含1%,2%甲基丙烯酰氧十二烷基溴吡抗菌单体的GLUMA Comfort Bond粘接剂对变形链球菌生长及产酸能力的抑制作用与阴性对照组相当(P >0.05),含3%,4%甲基丙烯酰氧十二烷基溴吡抗菌单体的GLUMA Comfort Bond粘接剂固化后对变形链球菌生长及产酸能力的抑制作用与阳性对照组相当(P >0.05).表明添加了3%,4%甲基丙烯酰氧十二烷基溴吡抗菌单体的实验性抗菌粘接试件具有良好的抗菌性能.
揹景:研究證實粘接脩複技術治療齲病過程中,齲洞預備後殘留的細菌可在牙體組織與脩複體之間繼續生存較長時間,誘髮繼髮齲或牙髓的慢性炎癥.目的:評價經甲基丙烯酰氧十二烷基溴吡單體改性樹脂基粘接劑對變形鏈毬菌的抗菌性能.方法:製備含質量分數0(陰性對照),1%,2%,3%,4%甲基丙烯酰氧十二烷基溴吡抗菌單體的實驗性GLUMA Comfort Bond粘接劑樣本,以Clearfil Protect bond粘接劑為暘性對照;分彆塗佈在複閤樹脂試件錶麵併固化,在變形鏈毬菌液體培養基中進行培養,培養18 h後檢測菌液的A值、pH值.結果與結論:GLUMA Comfort Bond 粘接劑對變形鏈毬菌生長及產痠能力無明顯抑製作用,Clearfil Protect bond粘接劑對變形鏈毬菌生長及產痠能力有明顯抑製作用.含1%,2%甲基丙烯酰氧十二烷基溴吡抗菌單體的GLUMA Comfort Bond粘接劑對變形鏈毬菌生長及產痠能力的抑製作用與陰性對照組相噹(P >0.05),含3%,4%甲基丙烯酰氧十二烷基溴吡抗菌單體的GLUMA Comfort Bond粘接劑固化後對變形鏈毬菌生長及產痠能力的抑製作用與暘性對照組相噹(P >0.05).錶明添加瞭3%,4%甲基丙烯酰氧十二烷基溴吡抗菌單體的實驗性抗菌粘接試件具有良好的抗菌性能.
배경:연구증실점접수복기술치료우병과정중,우동예비후잔류적세균가재아체조직여수복체지간계속생존교장시간,유발계발우혹아수적만성염증.목적:평개경갑기병희선양십이완기추필단체개성수지기점접제대변형련구균적항균성능.방법:제비함질량분수0(음성대조),1%,2%,3%,4%갑기병희선양십이완기추필항균단체적실험성GLUMA Comfort Bond점접제양본,이Clearfil Protect bond점접제위양성대조;분별도포재복합수지시건표면병고화,재변형련구균액체배양기중진행배양,배양18 h후검측균액적A치、pH치.결과여결론:GLUMA Comfort Bond 점접제대변형련구균생장급산산능력무명현억제작용,Clearfil Protect bond점접제대변형련구균생장급산산능력유명현억제작용.함1%,2%갑기병희선양십이완기추필항균단체적GLUMA Comfort Bond점접제대변형련구균생장급산산능력적억제작용여음성대조조상당(P >0.05),함3%,4%갑기병희선양십이완기추필항균단체적GLUMA Comfort Bond점접제고화후대변형련구균생장급산산능력적억제작용여양성대조조상당(P >0.05).표명첨가료3%,4%갑기병희선양십이완기추필항균단체적실험성항균점접시건구유량호적항균성능.
@@@@BACKGROUND: During the treatment of dental caries with bonding repair technique, residual bacteria fol owing the preparation of cavities can survive a long time between the tooth structure and dental prosthesis, which can cause secondary caries or chronic inflammation of the pulp. OBJECTIVE: To evaluate the antibacterial effects of resin-based adhesive modified with the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide against Streptococcus mutans. METHODS: Experimental antibacterial adhesive specimens (GLUMA Comfort Bond) covered with different concentrations of antibacterial monomers (0 as negative control, 1%, 2%, 3%, 4% 12-methacryloyloxydodecylpyridinium bromide) were prepared, and their antibacterial effects were investigated by the measurement of bacteria liquid absorbance, pH value which contained experimental antibacterial adhesive specimens after 18-hour culture. Clearfil Protect Bond was used as positive control. RESULTS AND CONCLUSION: There was statistical difference in antibacterial effects between the negative control and positive control. The experimental adhesive specimens incorporated with 1% and 2% monomers showed antibacterial activities against Streptococcus mutans similar as the negative control (P > 0.05). There was no statistical difference in antibacterial effects between the positive control and experimental adhesive specimens incorporated with 3% and 4% monomers (P > 0.05). These findings indicate that experimental adhesive specimens containing 3% and 4% 12-methacryloyloxydodecylpyridinium bromide monomers showed better antibacterial activities.
