CAJ | 학술논문

生物材料%材料生物相容性%双组分室温硫化硅橡胶%人工晶状体%氧气等离子体%表面改性%生物相容性%晶状体上皮细胞%亲水性%省级基金生物材料%材料生物相容性%雙組分室溫硫化硅橡膠%人工晶狀體%氧氣等離子體%錶麵改性%生物相容性%晶狀體上皮細胞%親水性%省級基金
생물재료%재료생물상용성%쌍조분실온류화규상효%인공정상체%양기등리자체%표면개성%생물상용성%정상체상피세포%친수성%성급기금
biomaterials%material biocompatibility%bicomponent room temperature vulcanized polydimethylsiloxane%intraocular lens%oxygen plasma treatment%surface modification%biocompatibility%lens epithelial cells%hydrophilicity%provincial grants-supported paper

背景:氧等离子处理可有效改善双组分室温硫化硅橡胶人工晶状体材料表面的亲水性能和生物相容性,但等离子体聚合形成的薄膜可能产生卷曲和破裂或因与基质是非共价键结合而产生剥离,影响材料本身的理化性能和光学性能.目的:初步评价优选氧等离子处理表面改性后双组分室温硫化硅橡胶人工晶状体材料的体外生物相容性.方法:采用氧等离子体表面改性技术修饰疏水性双组分室温硫化硅橡胶人工晶状体材料的表面,处理功率及时间分别为:20 W、50 W、100 W和30 s、1 min、3 min、10 min.应用视频光学接触角测定仪、傅里叶变换衰减全反射红外光谱和X射线光电子能谱分析材料表面亲水性和表面化学元素组成;扫描电子显微镜和原子力显微镜观察材料表面形貌.通过人晶状体上皮细胞黏附实验观察双组分室温硫化硅橡胶表面改性前后细胞的数量及形态改变.结果与结论:最佳改性条件为100 W,30 s,20 mL/min,40 Pa.此条件改善了双组分室温硫化硅橡胶人工晶状体材料表面的亲水性,对材料表面无刻蚀作用,改善了人晶体上皮细胞在双组分室温硫化硅橡胶人工晶状体材料表面的生物相容性.
배경:양등리자처리가유효개선쌍조분실온류화규상효인공정상체재료표면적친수성능화생물상용성,단등리자체취합형성적박막가능산생권곡화파렬혹인여기질시비공개건결합이산생박리,영향재료본신적이화성능화광학성능.목적:초보평개우선양등리자처리표면개성후쌍조분실온류화규상효인공정상체재료적체외생물상용성.방법:채용양등리자체표면개성기술수식소수성쌍조분실온류화규상효인공정상체재료적표면,처리공솔급시간분별위:20 W、50 W、100 W화30 s、1 min、3 min、10 min.응용시빈광학접촉각측정의、부리협변환쇠감전반사홍외광보화X사선광전자능보분석재료표면친수성화표면화학원소조성;소묘전자현미경화원자력현미경관찰재료표면형모.통과인정상체상피세포점부실험관찰쌍조분실온류화규상효표면개성전후세포적수량급형태개변.결과여결론:최가개성조건위100 W,30 s,20 mL/min,40 Pa.차조건개선료쌍조분실온류화규상효인공정상체재료표면적친수성,대재료표면무각식작용,개선료인정체상피세포재쌍조분실온류화규상효인공정상체재료표면적생물상용성.
@@@@BACKGROUND: Oxygen plasma treatment can greatly improve the hydrophilicity and biocompatibility of bicomponent room temperature vulcanized polydimethylsiloxane intraocular lens. However, plasma-aggravated thin film may curl, rupture or dissect due to binding with matrix noncovalent bond, thus affecting the physicochemical properties and optical performance of the material. OBJECTIVE: To evaluate the in vitro biocompatibility of bicomponent room temperature vulcanized polydimethylsiloxane intraocular lens materials after oxygen plasma processing. METHODS: Oxygen plasma treatment was employed to optimize the surface of intraocular lens materials using the surface modification technique. The power and duration were 20 W, 50 W, 100 W, and 30 seconds, 1 minute, 10 minutes, respectively. Water contact angle, fourier transform infrared spectroscopy-attenuated total reflection, X-ray photo electron spectroscopy analysis were adopted to analyze the hydrophilicity and the surface chemical composition of the material. Scanning electron microscopy and atomic force microscope were used to observe the surface morphology. Cel ular adhesion was performed by seeding human lens epithelial cel s onto the surface of the materials to evaluate the effect of surface modification on its biocompatibility. RESULTS AND CONCLUSION: The surface modification of intraocular lens materials by oxygen plasma treatment under optimal conditions (100 W, 30 seconds, 20 mL/min, 40 Pa) could improve the surface hydrophilicity and biocompatibility of the material without etching effect.