CAJ | 학술논문

端粒酶是由RNA模板和蛋白亚基构成的一种高度特异性的核糖核蛋白复合体.它能通过保持端粒长度的动态平衡和调节p53-p21-pRb通路、p16Ink41-pRb通路和Wnt/β-catenin信号通路来延长椎间盘细胞的寿命和保持细胞功能,进而延缓或阻止椎间盘退变的进程.端粒酶能调节椎间盘细胞的衰老和凋亡,可望运用端粒酶基因对椎间盘退变进行预防和修复重建其结构.
단립매시유RNA모판화단백아기구성적일충고도특이성적핵당핵단백복합체.타능통과보지단립장도적동태평형화조절p53-p21-pRb통로、p16Ink41-pRb통로화Wnt/β-catenin신호통로래연장추간반세포적수명화보지세포공능,진이연완혹조지추간반퇴변적진정.단립매능조절추간반세포적쇠로화조망,가망운용단립매기인대추간반퇴변진행예방화수복중건기결구.
Telomerase, as a highly specific ribonucleoprotein, is composed by the RNA template and protein subunits. It can delay or prevent the process of disc degeneration by maintaining telomere length homeostasis as well as affecting the p53-p21-pRb pathway, p16Ink41-pRb pathway and Wnt/β-catenin signal pathway. Telomerase can regulate the senescence and apoptosis of intervertebral disc cell, expected to prevention and repair reconstruction of the structure by telomerase gene therapy of intervertebral disc degeneration.